TY - BOOK AU - Loscalzo, Joseph, Ed...[et al...] TI - Harrison's Principles of Internal Medicine, Vol.1 SN - 9781264285822 PY - 2022/// CY - New York PB - Mc Graw Hill KW - Internal medicine; Medicine N1 - Part 1: The Profession of Medicine Chapter 1: The Practice of Medicine Chapter 2: Promoting Good Health Chapter 3: Vaccine Opposition and Hesitancy Chapter 4: Decision-Making in Clinical Medicine Chapter 5: Precision Medicine and Clinical Care Chapter 6: Screening and Prevention of Disease Chapter 7: Global Diversity of Health System Financing and Delivery Chapter 8: The Safety and Quality of Health Care Chapter 9: Diagnosis: Reducing Errors and Improving Quality Chapter 10: Racial and Ethnic Disparities in Health Care Chapter 11: Ethical Issues in Clinical Medicine Chapter 12: Palliative and End-of-Life Care Part 2: Cardinal Manifestations and Presentation of Diseases Section 1: Pain Chapter 13: Pain: Pathophysiology and Management Chapter 14: Chest Discomfort Chapter 15: Abdominal Pain Chapter 16: Headache Chapter 17: Back and Neck Pain Section 2: Alterations in Body Temperature Chapter 18: Fever Chapter 19: Fever and Rash Chapter 20: Fever of Unknown Origin Section 3: Nervous System Dysfunction Chapter 21: Syncope Chapter 22: Dizziness and Vertigo Chapter 23: Fatigue Chapter 24: Neurologic Causes of Weakness and Paralysis Chapter 25: Numbness, Tingling, and Sensory Loss Chapter 26: Gait Disorders, Imbalance, and Falls Chapter 27: Confusion and Delirium Chapter 28: Coma Chapter 29: Dementia Chapter 30: Aphasia, Memory Loss, and Other Cognitive Disorders Chapter 31: Sleep Disorders Section 4: Disorders of Eyes, Ears, Nose, and Throat Chapter 32: Disorders of the Eye Chapter 33: Disorders of Smell and Taste Chapter 34: Disorders of Hearing Chapter 35: Upper Respiratory Symptoms, Including Earache, Sinus Symptoms, and Sore Throat Chapter 36: Oral Manifestations of Disease Section 5: Alterations in Circulatory and Respiratory Functions Chapter 37: Dyspnea Chapter 38: Cough Chapter 39: Hemoptysis Chapter 40: Hypoxia and Cyanosis Chapter 41: Edema Chapter 42: Approach to the Patient with a Heart Murmur Chapter 43: Palpitations Section 6: Alterations in Gastrointestinal Function Chapter 44: Dysphagia Chapter 45: Nausea, Vomiting, and Indigestion Chapter 46: Diarrhea and Constipation Chapter 47: Unintentional Weight Loss Chapter 48: Gastrointestinal Bleeding Chapter 49: Jaundice Chapter 50: Abdominal Swelling and Ascites Section 7: Alterations in Renal and Urinary Tract Function Chapter 51: Interstitial Cystitis/Bladder Pain Syndrome Chapter 52: Azotemia and Urinary Abnormalities Chapter 53: Fluid and Electrolyte Disturbances Chapter 54: Hypercalcemia and Hypocalcemia Chapter 55: Acidosis and Alkalosis Section 8: Alterations in the Skin Chapter 56: Approach to the Patient with a Skin Disorder Chapter 57: Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders Chapter 58: Skin Manifestations of Internal Disease Chapter 59: Immunologically Mediated Skin Diseases Chapter 60: Cutaneous Drug Reactions Chapter 61: Photosensitivity and Other Reactions to Sunlight Section 9: Hematologic Alterations Chapter 62: Interpreting Peripheral Blood Smears Chapter 63: Anemia and Polycythemia Chapter 64: Disorders of Granulocytes and Monocytes Chapter 65: Bleeding and Thrombosis Chapter 66: Enlargement of Lymph Nodes and Spleen Part 3: Pharmacology Chapter 67: Principles of Clinical Pharmacology Chapter 68: Pharmacogenomics Part 4: Oncology and Hematology Section 1: Neoplastic Disorders Chapter 69: Approach to the Patient with Cancer Chapter 70: Prevention and Early Detection of Cancer Chapter 71: Cancer Genetics Chapter 72: Cancer Cell Biology Chapter 73: Principles of Cancer Treatment Chapter 74: Infections in Patients with Cancer Chapter 75: Oncologic Emergencies Updated! Chapter 76: Cancer of the Skin Chapter 77: Head and Neck Cancer Chapter 78: Neoplasms of the Lung Chapter 79: Breast Cancer Chapter 80: Upper Gastrointestinal Tract Cancers Chapter 81: Lower Gastrointestinal Cancers Chapter 82: Tumors of the Liver and Biliary Tree Chapter 83: Pancreatic Cancer Chapter 84: Gastrointestinal Neuroendocrine Tumors Chapter 85: Renal Cell Carcinoma Chapter 86: Cancer of the Bladder and Urinary Tract Chapter 87: Benign and Malignant Diseases of the Prostate Chapter 88: Testicular Cancer Chapter 89: Gynecologic Malignancies Chapter 90: Primary and Metastatic Tumors of the Nervous System Chapter 91: Soft Tissue and Bone Sarcomas and Bone Metastases Chapter 92: Carcinoma of Unknown Primary Chapter 93: Paraneoplastic Syndromes: Endocrinologic/Hematologic Chapter 94: Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis Chapter 95: Cancer Survivorship and the Long-Term Impact of Cancer and Its Treatment Section 2: Hematopoietic Disorders Chapter 96: Hematopoietic Stem Cells Chapter 97: Iron Deficiency and Other Hypoproliferative Anemias Chapter 98: Disorders of Hemoglobin Chapter 99: Megaloblastic Anemias Chapter 100: Hemolytic Anemias Chapter 101: Anemia Due to Acute Blood Loss Chapter 102: Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia Chapter 103: Polycythemia Vera and Other Myeloproliferative Neoplasms Chapter 104: Acute Myeloid Leukemia Chapter 105: Chronic Myeloid Leukemia Chapter 106: Acute Lymphoid Leukemia Chapter 107: Chronic Lymphocytic Leukemia Chapter 108: Non-Hodgkin’s Lymphoma Chapter 109: Hodgkin’s Lymphoma Chapter 110: Less Common Lymphoid and Myeloid Malignancies Chapter 111: Plasma Cell Disorders Chapter 112: Amyloidosis Chapter 113: Transfusion Therapy and Biology Chapter 114: Hematopoietic Cell Transplantation Section 3: Disorders of Hemostasis Chapter 115: Disorders of Platelets and Vessel Wall Chapter 116: Coagulation Disorders Chapter 117: Arterial and Venous Thrombosis Chapter 118: Antiplatelet, Anticoagulant, and Fibrinolytic Drugs Part 5: Infectious Diseases Section 1: Basic Considerations in Infectious Diseases Chapter 119: Approach to the Patient with an Infectious Disease Chapter 120: Molecular Mechanisms of Microbial Pathogenesis Chapter 121: Microbial Genomics and Infectious Disease Updated! Chapter 122: Approach to the Acutely Ill Infected Febrile Patient Chapter 124: Health Recommendations for International Travel Chapter 123: Immunization Principles and Vaccine Use Chapter 125: Climate Change and Infectious Disease Section 2: Clinical Syndromes: Community-Acquired Infections Chapter 126: Pneumonia Chapter 127: Lung Abscess Chapter 128: Infective Endocarditis Chapter 129: Infections of the Skin, Muscles, and Soft Tissues Chapter 130: Infectious Arthritis Chapter 131: Osteomyelitis Chapter 132: Intraabdominal Infections and Abscesses Chapter 133: Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning Chapter 134: Clostridioides difficile Infection, Including Pseudomembranous Colitis Chapter 135: Urinary Tract Infections, Pyelonephritis, and Prostatitis Chapter 136: Sexually Transmitted Infections: Overview and Clinical Approach Updated! Chapter 137: Encephalitis Chapter 138: Acute Meningitis Chapter 139: Chronic and Recurrent Meningitis Chapter 140: Brain Abscess and Empyema Chapter 141: Infectious Complications of Bites Section 3: Clinical Syndromes: Health Care-Associated Infections Chapter 142: Infections Acquired in Health Care Facilities Chapter 143: Infections in Transplant Recipients Section 4: Therapy for Bacterial Diseases Chapter 144: Treatment and Prophylaxis of Bacterial Infections Chapter 145: Bacterial Resistance to Antimicrobial Agents Section 5: Diseases Caused by Gram-Positive Bacteria Chapter 146: Pneumococcal Infections Chapter 147: Staphylococcal Infections Chapter 148: Streptococcal Infections Chapter 149: Enterococcal Infections Chapter 150: Diphtheria and Other Corynebacterial Infections Chapter 151: Listeria monocytogenes Infections Chapter 152: Tetanus Chapter 153: Botulism Chapter 154: Gas Gangrene and Other Clostridial Infections Section 6: Diseases Caused by Gram-Negative Bacteria Chapter 155: Meningococcal Infections Chapter 156: Gonococcal Infections Chapter 157: Haemophilus and Moraxella Infections Chapter 158: Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria Chapter 159: Legionella Infections Chapter 160: Pertussis and Other Bordetella Infections Chapter 161: Diseases Caused by Gram-Negative Enteric Bacilli Chapter 162: Acinetobacter Infections Chapter 163: Helicobacter pylori Infections Chapter 164: Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species Chapter 165: Salmonellosis Updated! Chapter 166: Shigellosis Chapter 167: Infections Due to Campylobacter and Related Organisms Chapter 168: Cholera and Other Vibrioses Chapter 169: Brucellosis Chapter 170: Tularemia Chapter 171: Plague and Other Yersinia Infections Chapter 172: Bartonella Infections, Including Cat-Scratch Disease Chapter 173: Donovanosis Section 7: Miscellaneous Bacterial Infections Chapter 174: Nocardiosis Chapter 175: Actinomycosis Chapter 176: Whipple’s Disease Chapter 177: Infections Due to Mixed Anaerobic Organisms Section 8: Mycobacterial Diseases Chapter 178: Tuberculosis Chapter 179: Leprosy Chapter 180: Nontuberculous Mycobacterial Infections Chapter 181: Antimycobacterial Agents Section 9: Spirochetal Diseases Chapter 182: Syphilis Chapter 183: Endemic Treponematoses Updated! Chapter 184: Leptospirosis Chapter 185: Relapsing Fever and Borrelia miyamotoi Disease Chapter 186: Lyme Borreliosis Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae Chapter 187: Rickettsial Diseases Chapter 188: Infections Due to Mycoplasmas Chapter 189: Chlamydial Infections Section 11: Viral Diseases: General Considerations Chapter 190: Principles of Medical Virology Chapter 191: Antiviral Chemotherapy, Excluding Antiretroviral Drugs Section 12: Infections Due to DNA Viruses Chapter 192: Herpes Simplex Virus Infections Chapter 193: Varicella-Zoster Virus Infections Chapter 194: Epstein-Barr Virus Infections, Including Infectious Mononucleosis Chapter 195: Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8 Chapter 196: Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections Chapter 197: Parvovirus Infections Chapter 198: Human Papillomavirus Infections Section 13: Infections Due to DNA and RNA Respiratory Viruses Chapter 199: Common Viral Respiratory Infections, Including COVID-19 Chapter 200: Influenza Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses Chapter 201: The Human Retroviruses Chapter 202: Human Immunodeficiency Virus Disease: AIDS and Related Disorders Section 15: Infections Due to RNA Viruses Chapter 203: Viral Gastroenteritis Chapter 204: Enterovirus, Parechovirus, and Reovirus Infections Chapter 205: Measles (Rubeola) Chapter 206: Rubella (German Measles) Chapter 207: Mumps Chapter 208: Rabies and Other Rhabdovirus Infections Chapter 209: Arthropod-Borne and Rodent-Borne Virus Infections Chapter 210: Ebolavirus and Marburgvirus Infections Section 16: Fungal Infections Chapter 211: Pathogenesis, Diagnosis, and Treatment of Fungal Infections Chapter 212: Histoplasmosis Chapter 213: Coccidioidomycosis Chapter 214: Blastomycosis Chapter 215: Cryptococcosis Chapter 216: Candidiasis Chapter 217: Aspergillosis Chapter 218: Mucormycosis Chapter 219: Less Common Systemic Mycoses and Superficial Mycoses Chapter 220: Pneumocystis Infections Section 17: Protozoal and Helminthic Infections: General Considerations Chapter 221: Introduction to Parasitic Infections Chapter 222: Agents Used to Treat Parasitic Infections Section 18: Protozoal Infections Chapter 223: Amebiasis and Infection with Free-Living Amebae Chapter 224: Malaria Chapter 225: Babesiosis Chapter 226: Leishmaniasis Chapter 227: Chagas Disease and African Trypanosomiasis Chapter 228: Toxoplasma Infections Chapter 229: Protozoal Intestinal Infections and Trichomoniasis Section 19: Helminthic Infections Chapter 230: Introduction to Helminthic Infections Chapter 231: Trichinellosis and Other Tissue Nematode Infections Chapter 232: Intestinal Nematode Infections Chapter 233: Filarial and Related Infections Chapter 234: Schistosomiasis and Other Trematode Infections Chapter 235: Cestode Infections Part 6: Disorders of the Cardiovascular System Section 1: Introduction to Cardiovascular Disorders Chapter 236: Approach to the Patient with Possible Cardiovascular Disease Chapter 237: Basic Biology of the Cardiovascular System Chapter 238: Epidemiology of Cardiovascular Disease Section 2: Diagnosis of Cardiovascular Disorders Chapter 239: Physical Examination of the Cardiovascular System Chapter 240: Electrocardiography Chapter 241: Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging Chapter 242: Diagnostic Cardiac Catheterization and Coronary Angiography Section 3: Disorders of Rhythm Chapter 243: Principles of Clinical Cardiac Electrophysiology Chapter 244: The Bradyarrhythmias: Disorders of the Sinoatrial Node Chapter 245: The Bradyarrhythmias: Disorders of the Atrioventricular Node Chapter 246: Approach to Supraventricular Tachyarrhythmias Chapter 247: Physiologic and Nonphysiologic Sinus Tachycardia Chapter 248: Focal Atrial Tachycardia Chapter 249: Paroxysmal Supraventricular Tachycardias Chapter 250: Common Atrial Flutter and Macroreentrant and Multifocal Atrial Tachycardias Chapter 251: Atrial Fibrillation Chapter 252: Approach to Ventricular Arrhythmias Chapter 253: Premature Ventricular Contractions, Nonsustained Ventricular Tachycardia, and Accelerated Idioventricular Rhythm Chapter 254: Sustained Ventricular Tachycardia Chapter 255: Polymorphic Ventricular Tachycardia and Ventricular Fibrillation Chapter 256: Electrical Storm and Incessant Ventricular Tachycardia Section 4: Disorders of the Heart, Muscles, Valves, and Pericardium Chapter 257: Heart Failure: Pathophysiology and Diagnosis Chapter 258: Heart Failure: Management Chapter 259: Cardiomyopathy and Myocarditis Chapter 260: Cardiac Transplantation and Prolonged Assisted Circulation Chapter 261: Aortic Stenosis Chapter 262: Aortic Regurgitation Chapter 263: Mitral Stenosis Chapter 264: Mitral Regurgitation Chapter 265: Mitral Valve Prolapse Chapter 266: Tricuspid Valve Disease Chapter 267: Pulmonic Valve Disease Chapter 268: Multiple and Mixed Valvular Heart Disease Chapter 269: Congenital Heart Disease in the Adult Chapter 270: Pericardial Disease Chapter 271: Atrial Myxoma and Other Cardiac Tumors Chapter 272: Cardiac Trauma Section 5: Coronary and Peripheral Vascular Disease Chapter 273: Ischemic Heart Disease Chapter 274: Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina) Chapter 275: ST-Segment Elevation Myocardial Infarction Chapter 276: Percutaneous Coronary Interventions and Other Interventional Procedures Chapter 277: Hypertension Chapter 278: Renovascular Disease Chapter 279: Deep-Venous Thrombosis and Pulmonary Thromboembolism Chapter 280: Diseases of the Aorta Chapter 281: Arterial Diseases of the Extremities Chapter 282: Chronic Venous Disease and Lymphedema Chapter 283: Pulmonary Hypertension Part 7: Disorders of the Respiratory System Section 1: Diagnosis of Respiratory Disorders Chapter 284: Approach to the Patient with Disease of the Respiratory System Chapter 285: Disturbances of Respiratory Function Chapter 286: Diagnostic Procedures in Respiratory Disease Section 2: Diseases of the Respiratory System Chapter 287: Asthma Chapter 288: Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia Chapter 289: Occupational and Environmental Lung Disease Chapter 291: Cystic Fibrosis Chapter 290: Bronchiectasis Chapter 292: Chronic Obstructive Pulmonary Disease Chapter 293: Interstitial Lung Disease Chapter 294: Disorders of the Pleura Chapter 295: Disorders of the Mediastinum Chapter 296: Disorders of Ventilation Chapter 297: Sleep Apnea Chapter 298: Lung Transplantation Chapter 299: Interventional Pulmonary Medicine Part 8: Critical Care Medicine Section 1: Respiratory Critical Care Chapter 300: Approach to the Patient with Critical Illness Chapter 301: Acute Respiratory Distress Syndrome Chapter 302: Mechanical Ventilatory Support Section 2: Shock and Cardiac Arrest Chapter 303: Approach to the Patient with Shock Chapter 304: Sepsis and Septic Shock Chapter 305: Cardiogenic Shock and Pulmonary Edema Chapter 306: Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death Section 3: Neurologic Critical Care Chapter 307: Nervous System Disorders in Critical Care Part 9: Disorders of the Kidney and Urinary Tract Chapter 308: Approach to the Patient with Renal Disease or Urinary Tract Disease Chapter 309: Cell Biology and Physiology of the Kidney Chapter 310: Acute Kidney Injury Chapter 311: Chronic Kidney Disease Chapter 312: Dialysis in the Treatment of Kidney Failure Chapter 313: Transplantation in the Treatment of Renal Failure Chapter 314: Glomerular Diseases Chapter 315: Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development Chapter 316: Tubulointerstitial Diseases of the Kidney Chapter 317: Vascular Injury to the Kidney Chapter 318: Nephrolithiasis Chapter 319: Urinary Tract Obstruction Chapter 320: Interventional Nephrology Part 10: Disorders of the Gastrointestinal System Section 1: Disorders of the Alimentary Tract Chapter 321: Approach to the Patient with Gastrointestinal Disease Chapter 322: Gastrointestinal Endoscopy Chapter 323: Diseases of the Esophagus Chapter 324: Peptic Ulcer Disease and Related Disorders Chapter 325: Disorders of Absorption Chapter 326: Inflammatory Bowel Disease Chapter 327: Irritable Bowel Syndrome Chapter 328: Diverticular Disease and Common Anorectal Disorders Chapter 329: Mesenteric Vascular Insufficiency Chapter 330: Acute Intestinal Obstruction Chapter 331: Acute Appendicitis and Peritonitis Section 2: Nutrition Chapter 332: Nutrient Requirements and Dietary Assessment Chapter 333: Vitamin and Trace Mineral Deficiency and Excess Chapter 334: Malnutrition and Nutritional Assessment Chapter 335: Enteral and Parenteral Nutrition Section 3: Liver and Biliary Tract Disease Chapter 336: Approach to the Patient with Liver Disease Chapter 337: Evaluation of Liver Function Chapter 338: The Hyperbilirubinemias Chapter 339: Acute Viral Hepatitis Chapter 340: Toxic and Drug-Induced Hepatitis Chapter 341: Chronic Hepatitis Chapter 342: Alcohol-Associated Liver Disease Chapter 343: Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis Chapter 344: Cirrhosis and Its Complications Chapter 345: Liver Transplantation Chapter 346: Diseases of the Gallbladder and Bile Ducts Section 4: Disorders of the Pancreas Chapter 347: Approach to the Patient with Pancreatic Disease Chapter 348: Acute and Chronic Pancreatitis Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders Section 1: The Immune System in Health and Disease Chapter 349: Introduction to the Immune System Chapter 350: Mechanisms of Regulation and Dysregulation of the Immune System Chapter 351: Primary Immune Deficiency Diseases Section 2: Disorders of Immune-Mediated Injury Chapter 352: Urticaria, Angioedema, and Allergic Rhinitis Chapter 353: Anaphylaxis Chapter 354: Mastocytosis Chapter 355: Autoimmunity and Autoimmune Diseases Chapter 356: Systemic Lupus Erythematosus Chapter 357: Antiphospholipid Syndrome Chapter 358: Rheumatoid Arthritis Chapter 359: Acute Rheumatic Fever Chapter 360: Systemic Sclerosis (Scleroderma) and Related Disorders Chapter 361: Sjögren’s Syndrome Chapter 362: Spondyloarthritis Chapter 363: The Vasculitis Syndromes Chapter 364: Behçet Syndrome Chapter 365: Inflammatory Myopathies Chapter 366: Relapsing Polychondritis Chapter 367: Sarcoidosis Chapter 368: IgG4-Related Disease Chapter 369: Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases Section 3: Disorders of the Joints and Adjacent Tissues Chapter 370: Approach to Articular and Musculoskeletal Disorders Chapter 371: Osteoarthritis Chapter 372: Gout and Other Crystal-Associated Arthropathies Chapter 373: Fibromyalgia Chapter 374: Arthritis Associated with Systemic Disease, and Other Arthritides Chapter 375: Periarticular Disorders of the Extremities Part 12: Endocrinology and Metabolism Section 1: Endocrinology Chapter 376: Approach to the Patient with Endocrine Disorders Chapter 377: Mechanisms of Hormone Action Chapter 378: Physiology of Anterior Pituitary Hormones Chapter 379: Hypopituitarism Chapter 380: Pituitary Tumor Syndromes Chapter 381: Disorders of the Neurohypophysis Chapter 382: Thyroid Gland Physiology and Testing Chapter 383: Hypothyroidism Chapter 384: Hyperthyroidism and Other Causes of Thyrotoxicosis Chapter 385: Thyroid Nodular Disease and Thyroid Cancer Chapter 386: Disorders of the Adrenal Cortex Chapter 387: Pheochromocytoma Chapter 388: Multiple Endocrine Neoplasia Syndromes Chapter 389: Autoimmune Polyendocrine Syndromes Section 2: Sex- and Gender-Based Medicine Chapter 390: Sex Development Chapter 391: Disorders of the Testes and Male Reproductive System Chapter 392: Disorders of the Female Reproductive System Chapter 393: Menstrual Disorders and Pelvic Pain Chapter 394: Hirsutism Chapter 395: Menopause and Postmenopausal Hormone Therapy Chapter 396: Infertility and Contraception Chapter 397: Sexual Dysfunction Chapter 398: Women’s Health Chapter 399: Men’s Health Chapter 400: Lesbian, Gay, Bisexual, and Transgender (LGBT) Health Section 3: Obesity, Diabetes Mellitus, and Metabolic Syndrome Chapter 401: Pathobiology of Obesity Chapter 402: Evaluation and Management of Obesity Chapter 404: Diabetes Mellitus: Management and Therapies Chapter 403: Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology Chapter 405: Diabetes Mellitus: Complications Chapter 406: Hypoglycemia Chapter 407: Disorders of Lipoprotein Metabolism Chapter 408: The Metabolic Syndrome Section 4: Disorders of Bone and Mineral Metabolism Chapter 409: Bone and Mineral Metabolism in Health and Disease Chapter 410: Disorders of the Parathyroid Gland and Calcium Homeostasis Chapter 411: Osteoporosis Chapter 412: Paget’s Disease and Other Dysplasias of Bone Section 5: Disorders of Intermediary Metabolism Chapter 413: Heritable Disorders of Connective Tissue Chapter 414: Hemochromatosis Chapter 415: Wilson’s Disease Chapter 416: The Porphyrias Chapter 417: Disorders of Purine and Pyrimidine Metabolism Chapter 418: Lysosomal Storage Diseases Chapter 419: Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism Chapter 420: Inherited Disorders of Amino Acid Metabolism in Adults Chapter 421: Inherited Defects of Membrane Transport Part 13: Neurologic Disorders Section 1: Diagnosis of Neurologic Disorders Chapter 422: Approach to the Patient with Neurologic Disease Chapter 423: Neuroimaging in Neurologic Disorders Chapter 424: Pathobiology of Neurologic Diseases Section 2: Diseases of the Central Nervous System Chapter 425: Seizures and Epilepsy Chapter 426: Introduction to Cerebrovascular Diseases Updated! Chapter 427: Ischemic Stroke Chapter 428: Intracranial Hemorrhage Chapter 429: Subarachnoid Hemorrhage Chapter 430: Migraine and Other Primary Headache Disorders Chapter 431: Alzheimer’s Disease Chapter 432: Frontotemporal Dementia Chapter 433: Vascular Dementia Chapter 434: Dementia with Lewy Bodies Updated! Chapter 435: Parkinson’s Disease Chapter 436: Tremor, Chorea, and Other Movement Disorders Chapter 437: Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases Chapter 438: Prion Diseases Chapter 439: Ataxic Disorders Chapter 440: Disorders of the Autonomic Nervous System Chapter 441: Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders Chapter 442: Diseases of the Spinal Cord Chapter 443: Concussion and Other Traumatic Brain Injuries Chapter 444: Multiple Sclerosis Chapter 445: Neuromyelitis Optica Section 3: Nerve and Muscle Disorders Chapter 446: Peripheral Neuropathy Chapter 447: Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies Chapter 448: Myasthenia Gravis and Other Diseases of the Neuromuscular Junction Updated! Chapter 449: Muscular Dystrophies and Other Muscle Diseases Section 4: Chronic Fatigue Syndrome Chapter 450: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Section 5: Psychiatric and Addiction Disorders Chapter 451: Biology of Psychiatric Disorders Chapter 452: Psychiatric Disorders Chapter 453: Alcohol and Alcohol Use Disorders Chapter 454: Nicotine Addiction Chapter 455: Marijuana and Marijuana Use Disorders Chapter 456: Opioid-Related Disorders Chapter 457: Cocaine, Other Psychostimulants, and Hallucinogens Part 14: Poisoning, Drug Overdose, and Envenomation Chapter 458: Heavy Metal Poisoning Chapter 459: Poisoning and Drug Overdose Chapter 460: Disorders Caused by Venomous Snakebites and Marine Animal Exposures Chapter 461: Ectoparasite Infestations and Arthropod Injuries Part 15: Disorders Associated with Environmental Exposures Chapter 462: Altitude Illness Chapter 463: Hyperbaric and Diving Medicine Chapter 464: Hypothermia and Peripheral Cold Injuries Chapter 465: Heat-Related Illnesses Part 16: Genes, the Environment, and Disease Chapter 466: Principles of Human Genetics Chapter 467: The Practice of Genetics in Clinical Medicine Chapter 468: Mitochondrial DNA and Heritable Traits and Diseases Chapter 469: Telomere Disease Chapter 470: Gene- and Cell-Based Therapy in Clinical Medicine Chapter 471: The Human Microbiome Part 17: Global Medicine Chapter 472: Global Issues in Medicine Chapter 473: Emerging and Reemerging Infectious Diseases Chapter 474: Primary Care and Global Health Chapter 475: Health Effects of Climate Change Part 18: Aging Chapter 476: Biology of Aging Chapter 477: Caring for the Geriatric Patient Part 19: Consultative Medicine Chapter 478: Approach to Medical Consultation Chapter 479: Medical Disorders During Pregnancy Chapter 480: Medical Evaluation of the Surgical Patient Part 20: Frontiers Chapter 481: Behavioral Economics and Health Chapter 482: Complementary and Integrative Therapies and Practices Chapter 483: The Role of Epigenetics in Disease and Treatment Chapter 484: Applications of Stem Cell Biology in Clinical Medicine Chapter 485: The Role of Circadian Biology in Health and Disease Chapter 486: Network Medicine: Systems Biology in Health and Disease Chapter 487: Emerging Neurotherapeutic Technologies Chapter 488: Machine Learning and Augmented Intelligence in Clinical Medicine Chapter 489: Metabolomics Chapter 490: Circulating Nucleic Acids as Liquid Biopsies and Noninvasive Disease Biomarkers Chapter 491: Protein Folding Disorders Chapter 492: Novel Approaches to Diseases of Unknown Etiology Part 21: Video Collection Chapter V1: Video Library of Gait Disorders Chapter V2: Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders Chapter V3: Video Library of Neuro-Ophthalmology Chapter V4: Examination of the Comatose Patient Chapter V5: Video Atlas of Gastrointestinal Endoscopic Lesions Chapter V6: The Neurologic Screening Exam Chapter V7: Video Atlas of the Detailed Neurologic Examination Part 22: Supplementary Topics Chapter S1: Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples Chapter S2: Cerebrospinal Fluid Disturbances: Case Examples Chapter S3: Microbial Bioterrorism Chapter S4: Chemical Terrorism Chapter S5: Radiation Terrorism Chapter S6: Infections in War Veterans Chapter S7: Health Care for Military Veterans Chapter S8: Primary Immunodeficiencies Associated with (or Secondary to) Other Diseases Chapter S9: Technique of Lumbar Puncture Chapter S10: The Clinical Laboratory in Modern Health Care Chapter S11: Laboratory Diagnosis of Infectious Diseases Chapter S12: Laboratory Diagnosis of Parasitic Infections Part 23: Atlases Chapter A1: Atlas of Rashes Associated with Fever Chapter A2: Atlas of Blood Smears of Malaria and Babesiosis Chapter A3: Atlas of Oral Manifestations of Disease Chapter A4: Atlas of Urinary Sediments and Renal Biopsies Chapter A5: Atlas of Skin Manifestations of Internal Disease Chapter A6: Atlas of Hematology Chapter A7: Atlas of Electrocardiography Chapter A8: Atlas of Cardiac Arrhythmias Chapter A9: Atlas of Noninvasive Imaging Chapter A10: Atlas of Atherosclerosis Chapter A11: Atlas of Percutaneous Revascularization and Adult Structural Heart Interventions Chapter A12: Atlas of Chest Imaging Chapter A13: Atlas of Liver Biopsies Chapter A14: Atlas of the Vasculitic Syndromes Chapter A15: Atlas of Clinical Manifestations of Endocrine and Metabolic Diseases Chapter A16: Atlas of Neuroimaging Part 24: Clinical Procedure Tutorials Chapter CP1: Clinical Procedure Tutorial: Central Venous Catheter Placement Chapter CP2: Clinical Procedure Tutorial: Thoracentesis Chapter CP3: Clinical Procedure Tutorial: Abdominal Paracentesis Chapter CP4: Clinical Procedure Tutorial: Endotracheal Intubation Chapter CP5: Clinical Procedure Tutorial: Percutaneous Arterial Blood Gas Sampling Chapter CP6: Clinical Procedure Tutorial: Lumbar Puncture Chapter CP7: Clinical Procedures Tutorial: Phlebotomy Chapter CP8: Clinical Procedures Tutorial: Insertion of Female Urethral Catheter Chapter CP9: Clinical Procedures Tutorial: Insertion of Male Urethral Catheter Chapter CP10: Clinical Procedures Tutorial: Fine Needle Aspiration of Breast Cyst Chapter CP11: Clinical Procedures Tutorial: IV Insertion Chapter CP12: Clinical Procedures Tutorial: Fine Needle Aspiration of Thyroid Nodules Chapter CP13: Clinical Procedures Tutorial: Gynecologic Examination with Pap Smear Chapter CP14: Clinical Procedures Tutorial: Knee Arthrocentesis Chapter CP15: Clinical Procedures Tutorial: Pericardiocentesis Chapter CP16: Clinical Procedures Tutorial: Bone Marrow Biopsy Chapter CP17: Clinical Procedures Tutorial: Basic Suturing ER -