05020nam a2200157Ia 450000500170000000800410001702000180005808200220007610000540009824500590015225000070021126000190021830000090023750045990024665000170484520260115114220.0210810s9999 xx 000 0 und d a9780323316965 a616.723 FIR-K10.2 aFirestiene Gary S ,Ralph C Budd Sherine E Gabriel 0a Kelley and Firestein's textbook of rheumatology Vol.2 a10 bElsevierc2017 a2086 aBiology of the normal joint Synovium Cartilage and chondrocytes Biology, physiology, and morphology of bone Muscle : anatomy, physiology, and biochemistry Biomechanics Regenerative medicine and tissue engineering Proteinases and matrix degradation Dendritic cells : general overview and role in autoimmunity Mononuclear phagocytes Neutrophils T lymphocytes B cells Fibroblasts and fibroblast-like synoviocytes Mast cells Platelets Innate immunity Adaptive immunity and organization of lymphoid tissues Autoimmunity Metabolic regulation of immunity Genetics of rheumatic diseases Epigenetics of rheumatic diseases Complement system Prostaglandins, leukotrienes, and related compounds Cell recruitment and angiogenesis Cytokines Principles of signaling Immunologic repercussions of cell death Experimental models for rheumatoid arthritis Neuronal regulation of pain and inflammation Clinical research methods in rheumatic disease Economic burden of rheumatic diseases Assessment of health outcomes Biologic markers in clinical trials and clinical care Occupational and recreational musculoskeletal disorders Cardiovascular risk in inflammatory rheumatic disease Cancer risk in rheumatic diseases Introduction to physical medicine, physical therapy, and rehabilitation Pregnancy and rheumatic diseases History and physical examination of the musculoskeletal system Acute monoarthritis Evaluation and differential diagnosis of polyarthritis Skin and rheumatic diseases The eye and rheumatic diseases Neck pain Shoulder pain Low back pain Hip and knee pain Foot and ankle pain Hand and wrist pain Temporomandibular joint pain Fibromyalgia Synovial fluid analyses, synovial biopsy, and synovial pathology Arthrocentesis and injection of joints and soft tissue Anti-nuclear antibodies Autoantibodies in rheumatoid arthritis Acute phase reactants and the concept of inflammation Imaging in rheumatic diseases Biology and therapeutic targeting of prostanoids Glucocorticoid therapy Traditional dmards : methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, and combination therapies Immunosuppressive drugs Anti-cytokine therapies Cell-targeted biologics and emerging targets : rituximab, abatacept, and other biologics Novel intra-cellular targeting agents in rheumatic disease Urate-lowering therapy Analgesic agents in rheumatic disease Nutrition and rheumatic diseases Etiology and pathogenesis of rheumatoid arthritis Clinical features of rheumatoid arthritis Treatment of rheumatoid arthritis Early synovitis and early undifferentiated arthritis Sjögren's syndrome Etiology and pathogenesis of spondyloarthritis Ankylosing spondylitis Undifferentiated spondyloarthritis Psoriatic arthritis Enteropathic arthritis Etiology and pathogenesis of systemic lupus erythematosus Clinical features of systemic lupus erythematosus Treatment of systemic lupus erythematosus Anti-phospholipid syndrome Etiology and pathogenesis of scleroderma Clinical features and treatment of scleroderma Inflammatory diseases of muscle and other myopathies Overlap syndromes Classification and epidemiology of systemic vasculitis Giant cell arteritis, polymyalgia rheumatica, and Takayasu's arteritis Anti-neutrophil cytoplasmic antibody associated vasculitis Polyarteritis nodosa and related disorders Immune complex mediated small-vessel vasculitis Primary angiitis of the central nervous system Behçet's disease Etiology and pathogenesis of hyperuricemia and gout Clinical features and treatment of gout Calcium crystal disease : calcium pyrophosphate dihydrate and basic calcium phosphate Familial autoinflammatory syndromes Pathogenesis of osteoarthritis Clinical features of osteoarthritis Treatment of osteoarthritis Metabolic bone disease Proliferative bone diseases Osteonecrosis Relapsing polychondritis Heritable diseases of connective tissue Etiology and pathogenesis of juvenile idiopathic arthritis Clinical features and treatment of juvenile idiopathic arthritis Pediatric systemic lupus erythematosus, juvenile dermatomyositis, scleroderma, and vasculitis Bacterial arthritis Lyme disease Mycobacterial infections of bones and joints Fungal infections of bones and joints Rheumatic manifestations of human immunodeficiency virus infection Viral arthritis Rheumatic fever and post-streptococcal arthritis Amyloidosis Sarcoidosis Hemochromatosis Hemophilic arthropathy Rheumatic manifestations of hemoglobinopathies IgG4 -related disease Arthritis accompanying endocrine and metabolic disorders Musculoskeletal syndromes in malignancy Tumors and tumor-like lesions of joints and related structures aRheumatology