Preface v Farewell vii Contributors ix Acknowledgements xi Note from the authors and publishers xi Section 1 GENERAL Topics in drug therapy 3 (34) Clinical pharmacology 37 (4) Discovery and development of drugs 41 (10) Evaluation of drugs in man 51 (22) Official regulation of medicines 73 (10) Classification and naming of drugs 83 (6) Section 2 FROM PHARMACOLOGY TO TOXICOLOGY General pharmacology 89 (46) Unwanted effects and adverse drug reactions 135 (16) Poisoning, overdose, antidotes 151 (14) Nonmedical use of drugs 165 (36) Section 3 INFECTION AND INFLAMMATION Chemotherapy of infections 201 (14) Antibacterial drugs 215 (22) Chemotherapy of bacterial infections 237 (20) Viral, fungal, protozoal and helminthic infections 257 (22) Inflammation, arthritis and nonsteroidal anti-inflammatory drugs 279 (20) Drugs and the skin 299 (20) Section 4 NERVOUS SYSTEM Pain and analgesics 319 (26) Anaesthesia and neuromuscular block 345 (22) Psychotropic drugs 367 (46) Epilepsy, parkinsonism and allied conditions 413 (20) Section 5 CARDIORESPIRATORY AND RENAL SYSTEMS Cholinergic and antimuscarinic (anticholinergic) mechanisms and drugs 433 (14) Adrenergic mechanisms and drugs 447 (14) Arterial hypertension, angina pectoris, myocardial infarction 461 (36) Cardiac arrhythmia and cardiac failure 497 (24) Hyperlipidaemias 521 (8) Kidney and Genitourinary tract 529 (20) Respiratory system 549 (18) Section 6 BLOOD AND NEOPLASTIC DISEASE Drugs and haemostasis 567 (20) Cellular disorders and anaemias 587 (16) Neoplastic disease and immunosuppression 603 (22) Section 7 GASTROINTESTINAL SYSTEM Stomach, oesophagus and duodenum 625 (14) Intestines 639 (12) Liver, biliary tract, pancreas 651 (12) Section 8 ENDOCRINE SYSTEM, METABOLIC CONDITIONS Adrenal corticosteroids, antagonists, corticotrophin 663 (16) Diabetes mellitus, insulin, oral antidiabetes agents, obesity 679 (20) Thyroid hormones, antithyroid drugs 699 (10) Hypothalamic, pituitary and sex hormones 709 (26) Vitamins, calcium, bone 735 (10) Index