Introduction
1. The Practice of Medicine 2
Yash Pal Munjal
2. Disease Profi le and Epidemiology of Communicable and Non-communicable Diseases in India 11
Jugal Kishore
Part 2 Clinical Approach to Key Manifestations
1. Pain: Mechanism and Management 22
PN Kakar
2. Headache 24
K Ravishankar
3. Chest Pain 34
Sanjay Tyagi and Amit Mittal
4. Acute Abdomen: Non-surgical Causes 40
Sumeet Singla and AK Agarwal
5. Cough 47
Suman Kirti
6. Haemoptysis 52
Randeep Guleria and Jaya Kumar
7. Jaundice 56
Aparna Agrawal
8. Clinical Approach to Upper Gastrointestinal Bleeding 62
JC Vij
9. Approach to Patient with Lower Gastrointestinal Bleeding 65
Surinder S Rana
10. Fever of Unknown Origin 69
Priscilla Rupali
11. Generalised Lymphadenopathy 76
SK Verma
12. Dizziness and Vertigo 79
M Maiya
13. Syncope 83
Pushpa Yadav
14. Coma 87
B Vengamma
15. Appropriate Ordering of Radiological Investigations 94
Chandan J Das
16. A Clinical Approach to Patients with Ascites 107
Richa Dewan
17. Anasarca: A Clinical Approach 111
Yash Pal Munjal
18. Approach to a Patient with Dyspnoea 115
Praloy Chakraborty
19. Clinical Approach to Exanthematous Fever 120
Bibhuti Saha and Manab Kumar Ghosh
CONTENTS
Volume 1
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Part 3 Diagnostic Imaging
1. Conventional Radiology 126
Ashu Seith Bhalla and Manisha Jana
2. Ultrasound in Medicine 141
BS Rama Murthy
3. Computed Tomography 147
Bhavin Jankharia and Nishigandha Burute
4. Magnetic Resonance Imaging 156
Raju Sharma and Devasenathipathy Kandasamy
5. Nuclear Imaging 173
BR Mittal
6. Positron Emission Computed Tomography and Positron Emission Magnetic Resonance Imaging 186
Rakesh Kumar and Sellam Karunanithi
Part 4 Clinical Pharmacology
1. Drug Discovery and Clinical Evaluation of New Drugs 196
SK Gupta and Sushma Srivastava
2. Introduction to Pharmacology 204
CD Tripathi and Sachin Manocha
3. Rational Use of Medicines 210
Sangeeta Sharma
4. Pharmacokinetic and Pharmacodynamic Basis of Pharmacotherapy 213
Rajani Mathur
5. Pharmacovigilance: Safety Monitoring of Medicines 221
V Kalaiselvan
6. Role of National Formulary of India in National Health Care System 227
Jai Prakash and YK Gupta
Part 5 Immunology
1. An Overview of the Immune System 232
Sita Naik
2. General Concepts of Immuno-infl ammatory Disorders 242
Ramnath Misra
3. Immunology of Infectious Diseases 246
Sita Naik
4. Approach to a Patient with Suspected Primary Immunodefi ciency Disorder 249
Surjit Singh
5. Laboratory Investigations in Immune-mediated Diseases 256
Amita Aggarwal
6. Pharmacological Manipulation of the Immune System 261
Mitali Chatterjee and Alakendu Ghosh
7. Immunology of Organ and Haematopoietic Stem Cell Transplantation 270
Narinder K Mehra and Neeraj Kumar
Part 6 Medical Genetics
1. Introduction to Medical Genetics 278
Late Shyam Swarup Agarwal
2. Mendel and Beyond 282
Ratna Dua Puri
3. Clinical, Conventional and Molecular Cytogenetics 290
Ashutosh Halder
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4. Genetic Tests 301
Ashwin Dalal
5. Inborn Errors of Metabolism 306
Madhulika Kabra
6. Molecular Genetics, Human Genome Project and Genomic Medicine 316
Girisha KM
7. Gene Therapy 322
Rita Mulherkar
8. Genetic Counselling and Prenatal Diagnosis 325
Shubha R Phadke
9. Pharmacogenomics and Personalised Medicine 332
C Adithan
10. Cancer Genetics 335
Rajiv Sarin
Part 7 Critical Care Medicine
1. Basic Considerations in Critical Care 342
RK Mani and P Saxena
2. Monitoring of Critically Ill Patients 346
M Hanumantha Rao
3. Fluid and Electrolyte Balance in Health and Disease 352
Sanjay Jain
4. Acid-Base Disorders 360
Alladi Mohan and Surendra K Sharma
5. Enteral and Parenteral Nutrition in Critically Ill Patients 368
Shilpa S Joshi
6. Acute Respiratory Failure 374
Ashit M Bhagwati
7. Sepsis and Acute Respiratory Distress Syndrome 381
Alladi Mohan and Surendra K Sharma
8. Mechanical Ventilation 388
Tamilarasu Kadhiravan
9. Non-invasive Positive Pressure Ventilation 395
Dhruva Chaudhry and Rajesh Chawla
10. Hypotension and Shock 404
Piyush Jain and Rene P Eapen
11. Advanced Cardiac Life Support 407
Sanjeev Bhoi and Sameer Vankar
12. Brain Death and Support of Brain Dead Organ Donor 417
Rajesh Chawla and Prashant Nasa
Part 8 Bone Disorders
1. Bone and Mineral Metabolism in Health and Disease 424
Deepak Khandelwal and Ravinder Goswami
2. Investigation and Diagnosis of Bone Disorders 430
Sukumar Mukherjee and Somnath Bhar
3. Rickets and Osteomalacia 437
Bindu Kulshreshtha and Sachin K Jain
4. Osteoporosis 442
SNA Rizvi
5. Developmental Disorders of Bone 448
Rakesh K Sahay
6. Miscellaneous Bone Disorders 451
CV Harinarayan
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Part 9 Diabetes Mellitus
1. Epidemiology and Basic Considerations of Diabetes 457
A Ramachandran and C Snehalatha
2. Pathogenesis of Type 1 Diabetes Mellitus 461
Carani B Sanjeevi and Vijay Viswanathan
3. Pathogenesis of Type 2 Diabetes Mellitus 465
Hemraj B Chandalia
4. Clinical Features and Diagnosis of Diabetes Mellitus 470
Anupam Prakash
5. Life-style Modifi cation in the Management of Diabetes 477
Banshi Saboo
6. Oral Antidiabetic Drugs 480
Anil Bhansali and Viral N Shah
7. Insulins 486
Yash Pal Munjal
8. Newer Modalities of Treatment in Type 2 Diabetes Mellitus 492
Anil Bhansali and G Shanmugasundar
9. In-Hospital Management of Diabetes Mellitus 497
Dukhabandhu Naik and Nihal Thomas
10. Hypoglycaemia 502
Siddharth N Shah
11. Diabetic Ketoacidosis, Hyperosmolar Hyperglycaemic State and Lactic Acidosis 508
Rajesh Rajput
12. Infections in Diabetes Mellitus 514
Samar Banerjee
13. Macrovascular Complications of Diabetes 519
Murlidhar S Rao
14. Microvascular Diseases: Pathogenesis of Chronic Complications 524
Suman Kirti
15. Diabetes and Kidney Disease 528
Raj Kumar Sharma
16. Diabetic Retinopathy 534
Amod Gupta and Reema Bansal
17. Diabetic Neuropathy 539
Manish Modi and Anu Gupta
18. Sexual Dysfunction in Diabetes 542
Shashank R Joshi
19. Management of Diabetic Foot 545
Rumneek Sodhi and Rajiv Parakh
20. Diabetes and Pregnancy 550
V Seshiah and V Balaji
21. Diabetes in the Elderly 554
Jamal Ahmad and Mohammad Asim Siddiqui
22. Prevention of Diabetes Mellitus 557
Yash Pal Munjal
Part 10 Endocrinology
1. Basic Considerations of Endocrinology 566
Ashok Kumar Das
2. Endocrine Disorders: A Clinical Approach 571
MS Seshadri
3. Disorders of Hypothalamus and Pineal Gland 576
Abdul Hamid Zargar and Shariq Rashid Masoodi
4. Disorders of Anterior Pituitary 580
RV Jayakumar
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5. Disorders of Posterior Pituitary 589
GR Sridhar
6. Disorders of Thyroid Glands 592
Nikhil Tandon and Nishant Raizada
7. Disorders of Parathyroid Glands 606
Ambrish Mithal and Beena Bansal
8. Disorders of Adrenal Glands 610
Eesh Bhatia and Vijayalakshmi Bhatia
9. Disorders of Puberty 621
AC Ammini and Jyotsna VP
10. Disorders of Growth and Development 626
Nalini S Shah
11. Disorders of Gonads 634
Shashank R Joshi
12. Endocrine Disorders of Female Gonads 645
Pikee Saxena and Aruna Nigam
Part 11 Dermatology
1. Introduction and Principles of Diagnosis in Dermatology 656
Vibhu Mendiratta
2. Infections and Infestations 665
Surabhi Dayal
3. Allergic and Infl ammatory Disorders 674
Sanjeev Handa
4. Psoriasis and Papulosquamous Disorders 678
Bela Shah
5. Acne and Acneiform Eruptions 685
V Ramesh
6. Bullous Diseases 691
Vibhu Mendiratta
7. Pigmentary Disorders 695
Sandipan Dhar
8. Cutaneous Responses to Environmental Factors 702
DM Thappa and M Malathi
9. Skin Manifestations of Systemic Diseases 708
Sunil Dogra and Rahul Mahajan
10. Pre-malignant Conditions and Malignant Tumours of the Skin 720
Arun C Inamadar and Aparna Palit
11. Sexually Transmitted Infections 724
Yogesh S Marfatia
12. Hair and Nail Disorders 733
S Sacchidanand and AS Savitha
13. Leprosy 741
Hemanta Kumar Kar
14. Dermatology Therapy 747
Asit Mittal
Part 12 Cardiology
1. Basic Considerations in Cardiology 757
Upendra Kaul and Aijaz H Mansoor
2. Cardiovascular Diseases: A Clinical Approach 763
GS Sainani
3. Electrocardiology 774
MJ Gandhi
Contents
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4. Exercise Testing 785
Yash Pal Munjal
5. Echocardiography 794
Satish Kumar Parashar
6. Cardiac Imaging 809
Priya Jagia and Sanjiv Sharma
7. Nuclear Cardiology 821
Vikram R Lele and Parag Aland
8. Cardiac Catheterisation and Angiocardiography 827
Lekha Adik Pathak and NO Bansal
9. Heart Failure 834
Donald Kikta and Veronica Franco
10. Treatment of Heart Failure 838
Veronica Franco and Khadijah Breathett
11. Acute Rheumatic Fever 845
R Krishna Kumar
12. Valvular Heart Disease (I) 854
CN Manjunath
13. Valvular Heart Disease (II) 862
VK Bahl and Neeraj Parakh
14. Infective Endocarditis 873
Shyam S Kothari
15. Atherosclerosis 884
KK Sethi and S Lahiri
16. Ischaemic Heart Disease 890
Inder S Anand and Shibba Takkar Chhabra
17. Acute Coronary Syndrome—NSTEMI 898
Ambuj Roy
18. Acute Myocardial Infarction—STEMI 904
Naved Aslam and Abhishek Goyal
19. Hypertension and Its Management 916
Sandhya A Kamath
20. Resistant Hypertension 930
BB Thakur and Smita Thakur
21. Bradyarrhythmias 935
Yash Y Lokhandwala and Gopi Krishna Panicker
22. Tachyarrhythmias 943
Amit Vora
23. Sudden Cardiac Arrest 950
Ashish K Thakur
24. Congenital Heart Disease 959
Sunita Maheshwari
25. Heart in Systemic Diseases 968
Aspi R Billimoria
26. Disorders of the Myocardium 973
KK Talwar and Ajay Bahl
27. Diseases of the Pericardium 985
Sanjay Tyagi and Amit Mittal
28. Surgical Management of Heart Disease 996
Muhammad Abid Geelani
29. Diseases of the Aorta 1005
Manotosh Panja and Soumitra Kumar
30. Vascular Disorders of the Extremities 1015
Gurpreet Singh Wander and Bishav Mohan
31. Pregnancy and Heart Disease 1023
Amal Kumar Banerjee
32. Prevention of Cardiovascular Diseases 1029
SKD Bhardwaj
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Part 13 Gastroenterology
1. Basic Considerations in Gastroenterology 1034
Vineet Ahuja and V Pratap Mouli
2. Clinical Approach to a Patient with Gastrointestinal Disease 1038
AC Anand and Pankaj Puri
3. Investigations: Gastrointestinal Disorders 1042
Ashok Chacko
4. Diagnostic and Therapeutic Utility of Endoscopy 1045
Gourdas Choudhuri
5. Oesophageal Disorders 1051
Shobna Bhatia and Deepak Kumar Gupta
6. Diseases of the Stomach and Duodenum 1061
Pankaj Dhawan and Rajesh Sainani
7. Gastrointestinal Bleeding 1069
Rakesh Kochhar and Jahangeer Basha
8. Acute Pancreatitis 1079
Pramod Kumar Garg
9. Chronic Pancreatitis 1092
V Balakrishnan and Gopalakrishna Rajesh
10. Neoplasms of the Pancreas 1098
V Balakrishnan and Gopalakrishna Rajesh
11. Functional Gastrointestinal Disorders 1103
Philip Abraham
12. Constipation: Diagnosis and Management 1108
Uday Chand Ghoshal
13. Diarrhoea and Malabsorption 1112
BS Ramakrishna
14. Abdominal Tuberculosis 1120
Govind K Makharia
15. Infl ammatory Bowel Disease 1128
Ajit Sood and Vandana Midha
16. Ischaemic Bowel Disorders 1134
Deepak Kumar Bhasin
17. Gastrointestinal Symptoms in Extra-abdominal and Systemic Diseases 1137
Sudeep Khanna and Rakesh Tandon
Part 14 Hepatology
1. Basic Considerations of Hepatobiliary Disorders 1144
Vivek Anand Saraswat
2. Hepatobiliary Disorders: Clinical Approach and Investigations 1148
Nagaraja Rao Padaki
3. Hepatobiliary Disorders: Imaging 1158
Shrinivas B Desai
4. Acute Viral Hepatitis 1167
DN Amarapurkar
5. Chronic Viral Hepatitis 1174
Radha K Dhiman
6. Chronic Non-viral Hepatitis 1181
CE Eapen
7. Alcoholic Liver Disease 1184
Rajesh Upadhyay and Nitin Gupta
8. Cirrhosis of the Liver 1190
Philip Abraham
9. Extrahepatic Portal Venous Obstruction 1196
Yogesh K Chawla
Contents
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10. Non-alcoholic Fatty Liver Disease 1199
Ajay Duseja
11. Acute Liver Failure 1204
SK Acharya and Shalimar
12. Inherited Metabolic Disorders of the Liver 1210
P Advaitham and Shanthi Vijayaragavan
13. Parasitic Diseases of the Liver 1216
MP Sharma and Vaibhav Gupta
14. Toxic and Drug-induced Liver Injury 1220
Abraham Koshy
15. Liver Transplantation 1222
Subash Gupta and Ajay Kumar
16. Pregnancy and Liver Diseases 1225
Ashish Goel
17. Liver in Systemic Diseases 1230
Premashis Kar and Rajiv Singla
18. Tumours of the Liver 1234
Kaushal Madan and Pankaj Tyagi
19. Diseases of the Gall Bladder and Biliary Tract 1238
Usha Dutta and Rakesh Tandon
Part 15 Haematology
1. Haematopoiesis 1245
Shaji V Ramachandran and Vikram Mathews
2. Anaemia: A Clinical Approach 1253
Renu Saxena and M Mahapatra
3. Splenomegaly: A Clinical Approach 1258
Pankaj Malhotra
4. Iron Defi ciency Anaemia 1262
Subhash Varma
5. Megaloblastic Anaemia 1268
Tarun Kumar Dutta
6. Hereditary Haemolytic Anaemia 1274
MB Agarwal
7. Acquired Haemolytic Anaemia 1285
Farah Jijina
8. Aplastic Anaemia 1291
Dharma R Choudhary and Tuphan Kanti Dolai
9. Acute Leukaemia 1297
SH Advani
10. Chronic Myeloid Leukaemia and Other Myeloproliferative Neoplasms 1306
Tapan Kumar Saikia
11. Myelodysplastic Syndromes 1310
Rajat Kumar and Seema Tyagi
12. Chronic Lymphocytic Leukaemia 1316
M Mahapatra and Renu Saxena
13. Hodgkin’s Lymphoma 1321
Bharath Rangarajan and PM Parikh
14. Non-Hodgkin’s Lymphoma 1327
Auro Viswabandya
15. Plasma Cell Dyscrasias 1331
Pankaj Manubhai Shah
16. Bleeding Disorders 1337
Kanjaksha Ghosh
17. Platelet Disorders 1341
Prantar Chakrabarti
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18. Idiopathic Thrombocytopenic Purpura 1346
Cecil Ross
19. Disorders of Coagulation 1351
Jina Bhattacharyya and Sangit Dutta
20. Hypercoagulable Disorders 1355
Mammen Chandy
21. Transfusion Medicine 1360
Neelam Marwaha
22. Haematopoietic Stem Cell Transplantation 1365
Velu Nair
Part 16 HIV and AIDS
1. Epidemiology of Human Immunodefi ciency Virus Infection 1374
OC Abraham and Susanne A Pulimood
2. HIV Virology and Immunology Including Diagnosis 1376
V Ravi and Anita Desai
3. Pathophysiology and Clinical Features 1380
UL Wagholikar and Alaka Deshpande
4. Antiretroviral Therapy 1386
BB Rewari
5. Drug Resistance 1390
Alaka Deshpande
6. Non-opportunistic Infections 1394
Anil Kumar Tripathi and D Himanshu
7. Opportunistic Infections 1398
Jyoti Wadhwa
8. Non-pharmacologic Interventions and Prevention 1403
R Sajithkumar
Contents
Part 17 Infectious Diseases
A. General Considerations
1. Basic Considerations of Infections 1411
Subhasish Kamal Guha
2. Laboratory Diagnosis of Infections 1414
Camilla Rodrigues and Niyati Desai
3. Syndromic Approach to Infectious Diseases 1422
Rajeev Soman and Neha Gupta
4. Antimicrobial Therapy 1429
Jagriti Bhatia and Dharamvir Singh Arya
5. Infection in the Immunocompromised Host 1437
Ghan Shyam Pangtey and Anupam Prakash
6. Hospital-acquired Infections/Nosocomial Infections 1440
A Shobhana
7. Prevention of Healthcare Associated Infections 1446
BB Rewari and Usha K Baveja
8. Hospital Infection Control 1452
Rohini Kelkar
B. Bacterial Infections
9. Staphylococcal Infections 1455
Rita Sood
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10. Streptococcal Infections 1460
Abhay Narain Rai
11. Pneumococcal Infections 1463
DP Bhadoria and Sanjay Pandit
12. Meningococcal Infections 1467
RK Singal and Vivek Pal Singh
13. Gonococcal Infections 1472
Chander Grover
14. Typhoid Fever (Enteric Fever) 1476
Swapan Kumar Niyogi
15. Bacillary Dysentery 1480
Pankaj Tyagi
16. Cholera 1483
Sujit K Bhattacharya and Sandipan Ganguly
17. Diseases Caused by Gram-negative Enteric Bacilli 1486
Richa Dewan
18. Haemophilus Infl uenzae Infections 1491
M Sabir and Mansoor Ahmed
19. Legionnaires’ Disease 1495
PS Shankar
20. Plague and Other Yersinia Infections 1498
Veena Mittal
21. Clostridial Infections 1502
MK Daga and Arvind Kumar
22. Diphtheria 1508
Sandeep B Bavdekar
23. Pertussis: Whooping Cough 1511
YK Amdekar
C. Miscellaneous Bacterial Infections
24. Syphilis 1514
Debabrata Bandyopadhyay
25. Non-syphilitic Treponematoses 1519
Taru Garg
26. Leptospirosis 1522
AP Sugunan
27. Other Spirochaetal Infections: Lyme Disease and Rat Bite Fever 1526
Kamlesh Tewary
28. Anaerobic Infections 1529
R Sajithkumar
29. Atypical Mycobacterial Infection 1531
Surendra Daga
30. Brucellosis 1534
BG Mantur
31. Donovanosis 1537
Dwijendra Nath Gangopadhyay
32. Actinomycosis and Nocardiosis 1539
A Muruganathan
33. Bartonella Infections 1542
Pallavi Bhargava
34. Melioidosis 1544
Kavitha Saravu
D. Rickettsial, Chlamydial and Mycoplasma Infections
35. Rickettsial Infections 1547
Mala Chhabra and Veena Mittal
36. Chlamydial Infections 1553
TK Suma
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37. Mycoplasma Infections 1556
Dilip Mathai
E. Viral Infections
38. Basic Considerations of Viral Diseases 1558
Usha K Baveja
39. Herpes Simplex Virus Infections 1565
Aditya Prakash Misra
40. Human Papillomavirus and Parvovirus Infections 1569
Neerja Bhatla and Biswa B Dash
41. Swine Flu/Avian Flu 1575
Arvind Mathur and Prabhu Prakash
42. Dengue 1580
ME Yeolekar and S Sukumaran
43. Ebola and Marburg Infections 1584
Partha Pratim Chakraborty
44. Japanese Encephalitis 1586
Deepshikha
45. Rabies 1590
Tarun Kumar Dutta
46. Viral Gastroenteritis 1595
Prabhash Chandra Bhattacharyya and Rupjyoti Talukdar
47. Mumps 1597
Falguni S Parikh
48. Measles (Rubeola) 1599
RK Goyal
49. Smallpox 1602
Ramesh Balwant Pandit
50. Lymphocytic Choriomeningitis 1604
Praveen Gupta
51. Prion Disease 1607
PK Maheshwari and Anjana Pandey
52. Human Babesiosis 1609
Yash Pal Munjal and Kusumita Chaudhuri
F. Protozoal Diseases
53. Malaria 1611
AK Agarwal and Sarit Chatterjee
54. Amoebiasis and Giardiasis 1620
MP Sharma and Vaibhav Gupta
55. Leishmaniasis 1624
Shyam Sundar
56. Toxoplasmosis 1629
Madhukar Rai
57. Trypanosomiasis 1632
Prashant P Joshi
58. Cryptosporidiosis, Trichomoniasis, Balantidiasis and Isosporiasis 1636
Atul Bhasin
G. Helminthic Diseases
59. Ankylostomiasis, Ascariasis and Other Nematodal Infections 1639
Narender Pal Jain
60. Tapeworm and Hydatid Diseases 1650
Anurag Saxena
61. Filariasis and Other Related Infestations 1658
Sanjay Zachariah
62. Schistosomiasis/Bilharziasis 1664
Kirti C Patel
Contents
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H. Fungal Infections
63. Systemic Fungal Infections 1667
Shruti Prem and Rajat Kumar
64. Pneumocystis Jirovecii Pneumonia 1678
V Ramasubramanian
Part 18 Disorders of Metabolism
1. Basic Considerations of Metabolism 1682
BK Sahay
2. Inborn Errors of Carbohydrate Metabolism 1684
Siddharth N Shah
3. Lipids and Lipoprotein Metabolism 1687
Soneil Guptha
4. Disorders of Purine and Pyrimidine Metabolism 1698
RV Jayakumar
5. Iron Metabolism and Iron Overload Syndrome 1700
Mukesh Desai
6. Porphyrias 1711
Dhanpat Kumar Kochar
7. Wilson’s Disease 1716
Sanjib Sinha and AB Taly
8. Lysosomal Storage Disorders 1722
Prasanta Kumar Bhattacharya
9. Inherited Disorders of Membrane Transport 1726
SK Singh
10. Amyloidosis 1730
Manisha Sahay
11. Disorders of Adipose Tissue and Obesity 1735
Shashank R Joshi
12. The Metabolic Syndrome 1740
Anoop Misra and Swati Bhardwaj
Part 19 Nephrology
1. Structure and Function of the Kidney 1744
Sandeep Mahajan and Yasir S Rizvi
2. Kidney Disease: A Clinical Approach 1750
Vijay Kher and Pranaw Kumar Jha
3. Acute Kidney Injury 1757
Alan F Almeida and Amit Langote
4. Chronic Kidney Disease 1762
Ashok L Kirpalani and Hardik Shah
5. Primary Glomerular Diseases 1772
Vinay Sakhuja and Raja Ramachandran
6. Secondary Glomerular Diseases 1783
OP Kalra and Sandeep Mahajan
7. Urinary Tract Infections 1791
R Kasi Visweswaran and Praveen Namboodiri
8. Nephrolithiasis and Urinary Tract Obstruction 1797
PD Gulati
9. Vascular Injury to Kidney 1802
AK Hooda and AS Narula
10. Polycystic Kidney Disease and Inherited Tubular Disorders 1807
PP Varma and Ranjith Nair
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11. Dialysis and Other Extracorporeal Therapies 1814
NK Hase
12. Renal Transplantation 1827
George T John
13. Tubulointerstitial Diseases of the Kidney 1833
Sree B Raju
14. Drug Nephrotoxicity and Renal Dosage Adjustment 1839
Ankur Gupta and Pritam Gupta
Part 20 Neurology
1. Neurological Disorders: Basic Consideration and Clinical Approach 1847
MV Padma Srivastava and RS Wadia
2. Clinical Neurophysiology 1859
J Kalita and UK Misra
3. Neuroimaging 1867
Rakesh K Gupta and Krishan K Jain
4. Epilepsy 1874
Sanjeev V Thomas
5. Disorders of Speech 1890
Apoorva Pauranik
6. Disorders of Cranial Nerves 1900
Sankar Prasad Gorthi and Sundaram Venkatraman
7. Ischaemic Cerebrovascular Diseases 1912
PM Dalal and M Bhattacharjee
8. Haemorrhagic Cerebrovascular Diseases 1926
MV Padma Srivastava and Ajay Garg
9. Cerebrovenous Thrombotic Disorders 1933
D Nagaraja and N Karthik
10. Bacterial Meningitis and Brain Abscess 1937
Ravindra Kumar Garg and Praveen Kumar Sharma
11. Neurotuberculosis 1944
Shyamal Kumar Das and Debal Laha
12. Neurosyphilis 1954
S Prabhakar and Manish Modi
13. Viral Infections of Central Nervous System 1958
Nadir E Bharucha
14. Slow Virus Infections and Prion Diseases 1966
SK Shankar
15. Fungal and Parasitic Diseases of the Nervous System 1971
Ashok Panagariya and Parul Dubey
16. Raised Intracranial Pressure and Hydrocephalus 1977
Daljit Singh
17. Dementia 1981
PS Mathuranath
18. Extrapyramidal Disorders 1987
BS Singhal
19. Cerebellar Disorders 1993
Netravathi M and Pramod Kumar Pal
20. Hyperkinetic Movement Disorders 2013
Mohit Bhatt
21. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases 2018
BK Bajaj
22. Demyelinating Diseases of Nervous System 2026
Man Mohan Mehndiratta and Prachi Mehndiratta
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23. Nutritional and Toxic Disorders of the Nervous System 2034
UK Misra
24. Metabolic Disorders of Nervous System 2041
Vrajesh Udani and Neelu Desai
25. Intracranial Space-occupying Lesions 2055
P Sarat Chandra and PN Tandon
26. Head Injury 2065
AK Singh
27. Peripheral Neuropathy 2073
AK Meena and SA Jabeen
28. Disorders of Autonomic Nervous System 2086
Garima Shukla
29. Myasthenia Gravis 2090
Sumit Singh and Atma Ram Bansal
30. Diseases of Muscles 2094
SV Khadilkar
31. Non-compressive Myelopathies 2107
Mrinal Kanti Roy
32. Compressive Myelopathies 2113
Vibhor Pardasani
Part 21 Oncology
1. Developments in Oncology 2120
Lalit Kumar and Prabhat Singh Malik
2. Principles of Cancer Biology and Pathology 2125
Anita M Borges
3. Cancer Screening and Prevention 2131
Atul Sharma and MP Ram Prabhu
4. Principles of Drug Treatment of Cancer 2134
Lalit Kumar and Prabhat Singh Malik
5. Principles of Radiotherapy 2143
GK Rath
6. Head and Neck Cancers 2147
VP Gangadharan
7. Breast Cancer 2150
Vinay H Deshmane
8. Tumours of the Gastrointestinal Tract (Stomach and Oesophagus) 2157
KM Mohandas
9. Colorectal Cancer 2164
K Govind Babu
10. Genitourinary Cancers 2167
Sudeep Gupta
11. Gynaecological Malignancies 2173
PP Bapsy
12. Bone and Soft Tissue Sarcoma 2180
Avinash Deo
13. Cancer of Unknown Primary Site 2184
Hemant Malhotra and Ashwin Mathur
14. Paraneoplastic Syndromes 2191
Senthil Rajappa and D Raghunadharao
15. Cancers in the Predisposed Host 2197
K Pavithran
16. Oncological Emergencies 2202
Avinash Deo
17. Supportive Care in Cancer 2206
Madhuchanda Kar and Rakesh Roy
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Part 22 Psychiatric Medicine
1. Introduction and Basic Considerations in Psychiatry 2212
Yatan Pal Singh Balhara and Koushik Sinha Deb
2. Organic Mental Disorders 2222
SK Khandelwal
3. Substance Use Disorders 2229
Debasish Basu
4. Psychosis and Schizophrenia 2236
R Thara and Shiva Prakash Srinivasan
5. Mood Disorders 2241
Yatan Pal Singh Balhara
6. Anxiety Disorders 2247
A Shyam Sundar and YC Janardhan Reddy
7. Somatoform Disorders 2254
Rakesh K Chadda
8. Emergency Psychiatry 2260
Dipesh Bhagabati
9. Sexual Disorders 2266
TS Sathyanarayana Rao and Abhinav Tandon
10. Biological and Somatic Treatment of Psychiatric Disorders 2276
E Mohandas and Rajmohan V
11. Psychotherapies in Mental Health 2284
Manoj K Sharma
Part 23 Pulmonary Medicine
1. Respiratory System: Basic Anatomy and Physiology 2290
SK Chhabra
2. Pulmonary Disorders: A Clinical Approach 2300
Jyotsna M Joshi
3. Diagnostic Procedures in Pulmonary Disorders 2306
Gautam Ahluwalia and Surendra K Sharma
4. Upper Respiratory Tract Infections 2313
DG Jain
5. Bronchial Asthma 2317
Virendra Singh
6. Chronic Obstructive Pulmonary Disease 2328
Surendra K Sharma
7. Pneumonia 2339
Digambar Behera
8. Suppurative Pleuro-pulmonary Diseases 2352
Sahajal Dhooria and Navneet Singh
9. Pulmonary Tuberculosis 2363
MS Jawahar
10. Fungal Infections of the Lungs 2371
Ashok Shah
11. Diff use Interstitial Lung Diseases 2378
Surinder K Jindal
12. Eosinophilic Lung Diseases and Tropical Pulmonary Eosinophilia 2388
VK Vijayan
13. Sarcoidosis 2395
VK Vijayan
14. Sleep-related Breathing Disorders 2403
R Narasimhan and AR Gayathri
15. Deep Venous Thrombosis and Pulmonary Embolism 2408
Jamshed D Sunavala and Shruti M Tandan
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16. Diseases of Pleura, Mediastinum, Diaphragm and Chest Wall 2417
Alladi Mohan
17. Benign and Malignant Tracheobronchial Tumours 2428
Lalit Kumar and MP Ram Prabhu
18. Atelectasis and Pulmonary Fibrosis 2438
Prasanta Raghab Mohapatra
19. Cor Pulmonale 2447
Sandeep Singh
20. Pulmonary Rehabilitation 2454
Sanjeev Sinha and Faraz Ahmed Farooqui
Part 24 Rheumatology
1. Basic Considerations of Rheumatology 2458
Rohini Handa
2. Soft Tissue Rheumatism and Regional Rheumatic Pain Syndromes 2463
Ved Chaturvedi
3. Low Back Pain 2469
Ghan Shyam Pangtey and Hemant Gopal
4. Osteoarthritis 2478
Siddharth Kumar Das
5. Gout and Other Crystal Arthritides 2483
URK Rao and Sripurna Deepti
6. Rheumatoid Arthritis 2492
AN Malaviya
7. Spondarthritides 2513
Milind Y Nadkar and Manish W Itolikar
8. Sjögren’s Syndrome 2522
Uma Kumar
9. Systemic Lupus Erythematosus 2525
VR Joshi
10. Antiphospholipid Syndrome 2534
Vikas Agarwal and Anupam Wakhlu
11. Infl ammatory Muscle Diseases 2539
Alakendu Ghosh and Pradyot Sinhamahapatra
12. Systemic Sclerosis 2545
Shefali Khanna Sharma
13. The Vasculitides 2549
Pradeep Bambery
14. Mixed Connective Tissue Disease and Overlap Syndromes 2560
G Narsimulu
15. Rheumatic Manifestations of Systemic Diseases 2564
Debashish Danda
16. Miscellaneous Rheumatic Disorders 2568
Binoy J Paul
17. Emergencies in Rheumatology 2574
Madhumita P Das
18. Tropical Rheumatic Diseases 2579
Aman Sharma
Part 25 Nutrition
1. Nutrition: Basic Considerations 2584
SV Madhu
2. Assessment of Nutritional Status 2589
Prema Ramachandran
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3. Protein Energy Malnutrition 2593
Piyush Gupta
4. Water-soluble Vitamins 2598
Milind Y Nadkar
5. Fat-soluble Vitamins 2603
Ghan Shyam Pangtey and Moti Lal
6. Minerals, Trace Elements and Antioxidants 2608
M Raghunath and D Sreeramulu
7. Food Allergy and Food Intolerance 2615
UV Mani
8. Eating Disorders 2618
Anupam Prakash
9. Enteral and Parenteral Nutrition Support 2621
Varsha
Part 26 Poisoning and Toxicology
1. Poisoning: Basic Considerations and Epidemiology 2628
Narinder Pal Singh and Gurleen Kaur
2. Aluminium Phosphide Poisoning 2632
Surjit Singh
3. Organophosphorous Poisoning 2634
Surjit Singh
4. Corrosive Poisoning 2637
Rakesh Kochhar
5. Alcohol Poisoning 2640
Pritam Gupta and Ankur Gupta
6. Plant Poisoning 2644
DKS Subrahmanyam and Muktha V
7. Drug Overdose 2649
Narinder Pal Singh
8. Snake Bite Poisoning 2656
HS Bawaskar
9. Scorpion Sting 2662
HS Bawaskar
10. Fluorosis 2670
D Raja Reddy
11. Lathyrism 2677
UK Misra and J Kalita
12. Epidemic Dropsy 2679
Vivek Suman and Shubha Laxmi Margekar
13. Heavy Metal Poisoning 2681
Praveen Aggarwal
14. Miscellaneous Poisonings 2693
Subhash Varma and Vikas Suri
Part 27 Environmental Medicine
1. Basic Considerations of Environmental and Occupational Diseases 2704
Randeep Guleria
2. Climate Change: Health and Disease 2707
Anil Gurtoo
3. Air Pollution and Public Health 2713
Anumita R Chowdhury
4. Air-borne Pollutants and Smoke-related Hazards 2719
Rajeev Gupta
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5. Drowning, Near Drowning and Submersion Injury 2725
Yudh Dev Singh
6. Electric Shock and Lightning Injury 2728
Naveet Wig and Sourabh Malviya
7. Eff ects of Extremes of Temperature 2731
Rajvir Bhalwar
8. High Altitude Medicine 2738
Anuj Chawla
9. Aerospace Medicine 2746
JS Kulkarni
10. Radiation Hazards 2752
AM Samuel
11. Environmental Disasters 2757
G Immanuel
Part 28 Miscellaneous
1. Oral Health and Systemic Diseases 2762
Akshay Munjal and Shilpa Khullar
2. Geriatric Medicine: An Overview 2766
Vinod Kumar
3. Frailty Syndrome 2771
ME Yeolekar and S Sukumaran
4. Polypharmacy in Elderly 2774
Jyotirmoy Pal and Sattik Siddhanta
5. Sexual Medicine 2778
Prakash Kothari
6. Sports Medicine 2783
Jaspal S Sandhu and Shweta Shenoy
7. Life-style Modifi cations to Prevent and Control Diseases 2787
Shridhar Dwivedi and Ramesh Aggarwal
8. Diet in Medical Diseases 2790
Siddharth N Shah
9. Tobacco Smoking-related Diseases and Tobacco Cessation 2800
Raj Kumar
10. Adult Immunisation 2805
AK Agarwal and Sumeet Singla
11. Travel Medicine 2818
Yash Pal Munjal and Aditya Prakash Misra
12. Perioperative Management 2825
Prabha Adhikari
13. Law and Medicine 2829
A Muruganathan and Yash Pal Munjal
14. Care of Terminally Ill 2834
Anil Chaturvedi
Part 29 Future of Medicine
1. Futuristic Medicine 2840
Yash Pal Munjal and Anupam Prakash
2. Regenerative Medicine 2846
Velu Nair
3. Introduction to Space Medicine 2854
R Gerzer
4. Nanotechnology and Nanomedicine 2861
RD Lele
5. Robotic Surgery 2868
Roman Dutta
Index I–1