A Beginner's Guide to Targeted Cancer Treatments (Record no. 50452)
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| fixed length control field | 03526nam a22001577a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230223102202.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230223b |||||||| |||| 00| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781119126799 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | <a href="Vickers, Elaine">Vickers, Elaine</a> |
| 245 ## - TITLE STATEMENT | |
| Title | A Beginner's Guide to Targeted Cancer Treatments |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | UK |
| Name of publisher, distributor, etc. | Wiley Blackwell |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 343 p. |
| 500 ## - GENERAL NOTE | |
| General note | TABLE OF CONTENTS<br/>Acknowledgments vii<br/><br/>About the Author ix<br/><br/>How to Use This Book xi<br/><br/>Chapter 1 An Introduction to Cancer Cell Biology and Genetics 1<br/><br/>1.1 Introduction 1<br/><br/>1.2 DNA Damage is the Cause of Every Cancer 2<br/><br/>1.3 The Defining Features (Hallmarks) of Cancer Cells 15<br/><br/>1.4 Genetic Variation among Cancer Cells in a Single Tumor 16<br/><br/>1.5 The Cancer Microenvironment 17<br/><br/>1.6 Cancer Spread/Metastasis 19<br/><br/>1.7 Cancer Stem Cells 23<br/><br/>1.8 Obstacles That Prevent us from Curing Cancer 24<br/><br/>1.9 Final Thoughts 28<br/><br/>Chapter 2 Introducing Targeted Cancer Treatments 33<br/><br/>2.1 Introduction 34<br/><br/>2.2 Monoclonal Antibodies 36<br/><br/>2.3 Kinase Inhibitors 48<br/><br/>2.4 Final Thoughts 60<br/><br/>Chapter 3 Treatments That Block Proteins Involved in Cell Communication 65<br/><br/>3.1 Introduction 65<br/><br/>3.2 Introducing Growth Factor Receptors 67<br/><br/>3.3 Drugs That Target EGFR 75<br/><br/>3.4 Drugs That Target HER2 81<br/><br/>3.5 Drugs That Block Other Growth Factor Receptors 85<br/><br/>3.6 Introduction to Signaling Pathways as a Target for Cancer Therapy 86<br/><br/>3.7 Targeting the MAPK Signaling Pathway 87<br/><br/>3.8 Targeting the PI3K/AKT/mTOR Signaling Pathway 94<br/><br/>3.9 Targeting the JAK-STAT Pathway 100<br/><br/>3.10 Final Thoughts 103<br/><br/>Chapter 4 Drugs That Target: Angiogenesis, Fusion Proteins, PARP, Hedgehog Signaling, and CDKs 111<br/><br/>4.1 Angiogenesis Inhibitors: Introduction 112<br/><br/>4.2 Drugs That Block Fusion Proteins: Bcr-Abl, ALK, RET, and ROS1 122<br/><br/>4.3 PARP Inhibitors 127<br/><br/>4.4 Hedgehog Pathway Inhibitors 134<br/><br/>4.5 Cyclin-Dependent Kinase (CDK) Inhibitors 139<br/><br/>4.6 Final Thoughts 145<br/><br/>Chapter 5 Immunotherapies for Cancer 151<br/><br/>5.1 Introduction 152<br/><br/>5.2 A Bit About Cancer and the Immune System 154<br/><br/>5.3 Checkpoint Inhibitors 160<br/><br/>5.4 Adoptive Cell Transfer 168<br/><br/>5.5 Modified Bi-specific Antibodies 175<br/><br/>5.6 Therapeutic Cancer Vaccines 176<br/><br/>5.7 The Future of Immunotherapy 181<br/><br/>Chapter 6 Targeted Treatments for Common Solid Tumors 187<br/><br/>6.1 Introduction 188<br/><br/>6.2 Targeted Treatments for Breast Cancer 188<br/><br/>6.3 Targeted Treatments for Prostate Cancer 200<br/><br/>6.4 Targeted Treatments for Lung Cancer 204<br/><br/>6.5 Targeted Treatments for Bowel Cancer 214<br/><br/>6.6 Targeted Treatments for Malignant Melanoma Skin Cancer 220<br/><br/>6.7 Targeted Treatments for Kidney Cancer 225<br/><br/>6.8 Targeted Treatments for Head and Neck Cancer 231<br/><br/>6.9 Targeted Treatments for Brain Tumors 235<br/><br/>6.10 Targeted Treatments for Bladder Cancer 236<br/><br/>6.11 Targeted Treatments for Pancreatic Cancer 240<br/><br/>6.12 Final Thoughts 244<br/><br/>Chapter 7 Targeted Treatments for Hematological Cancers 259<br/><br/>7.1 Introduction 259<br/><br/>7.2 A Bit About Hematological Cancers 260<br/><br/>7.3 Antibody-Based Treatments That Target CD Antigens 274<br/><br/>7.4 Drugs That Block B Cell Receptor Signaling 287<br/><br/>7.5 Bcr-Abl Inhibitors 292<br/><br/>7.6 Drugs That Block the Proteasome 294<br/><br/>7.7 Thalidomide and its Derivatives 297<br/><br/>7.8 JAK2 Inhibitors 298<br/><br/>7.9 Bcl-2 Inhibitors 299<br/><br/>7.10 FLT3 and KIT Inhibitors 301<br/><br/>7.11 IDH2 Inhibitors 304<br/><br/>7.12 CAR-Modified T Cell Therapy 304<br/><br/>7.13 Final Thoughts 304<br/><br/>Appendix 313<br/><br/>Glossary of Terms 315<br/><br/>Index 329 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cancer; Oncology |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Books |
| Withdrawn status | Lost status | Damaged status | Not for loan | Home library | Current library | Shelving location | Full call number | Barcode | Date last seen | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|
| MCK Central Library | MCK Central Library | General Stacks | 616.994 VIC-A | 19909 | 02/23/2023 | Books |