| General note |
Part 1: The Profession of Medicine<br/>Chapter 1: The Practice of Medicine<br/>Chapter 2: Promoting Good Health<br/>Chapter 3: Vaccine Opposition and Hesitancy<br/>Chapter 4: Decision-Making in Clinical Medicine<br/>Chapter 5: Precision Medicine and Clinical Care<br/>Chapter 6: Screening and Prevention of Disease<br/>Chapter 7: Global Diversity of Health System Financing and Delivery<br/>Chapter 8: The Safety and Quality of Health Care<br/>Chapter 9: Diagnosis: Reducing Errors and Improving Quality<br/>Chapter 10: Racial and Ethnic Disparities in Health Care<br/>Chapter 11: Ethical Issues in Clinical Medicine<br/>Chapter 12: Palliative and End-of-Life Care<br/>Part 2: Cardinal Manifestations and Presentation of Diseases<br/>Section 1: Pain<br/>Chapter 13: Pain: Pathophysiology and Management<br/>Chapter 14: Chest Discomfort<br/>Chapter 15: Abdominal Pain<br/>Chapter 16: Headache<br/>Chapter 17: Back and Neck Pain<br/>Section 2: Alterations in Body Temperature<br/>Chapter 18: Fever<br/>Chapter 19: Fever and Rash<br/>Chapter 20: Fever of Unknown Origin<br/>Section 3: Nervous System Dysfunction<br/>Chapter 21: Syncope<br/>Chapter 22: Dizziness and Vertigo<br/>Chapter 23: Fatigue<br/>Chapter 24: Neurologic Causes of Weakness and Paralysis<br/>Chapter 25: Numbness, Tingling, and Sensory Loss<br/>Chapter 26: Gait Disorders, Imbalance, and Falls<br/>Chapter 27: Confusion and Delirium<br/>Chapter 28: Coma<br/>Chapter 29: Dementia<br/>Chapter 30: Aphasia, Memory Loss, and Other Cognitive Disorders<br/>Chapter 31: Sleep Disorders<br/>Section 4: Disorders of Eyes, Ears, Nose, and Throat<br/>Chapter 32: Disorders of the Eye<br/>Chapter 33: Disorders of Smell and Taste<br/>Chapter 34: Disorders of Hearing<br/>Chapter 35: Upper Respiratory Symptoms, Including Earache, Sinus Symptoms, and Sore Throat<br/>Chapter 36: Oral Manifestations of Disease<br/>Section 5: Alterations in Circulatory and Respiratory Functions<br/>Chapter 37: Dyspnea<br/>Chapter 38: Cough<br/>Chapter 39: Hemoptysis<br/>Chapter 40: Hypoxia and Cyanosis<br/>Chapter 41: Edema<br/>Chapter 42: Approach to the Patient with a Heart Murmur<br/>Chapter 43: Palpitations<br/>Section 6: Alterations in Gastrointestinal Function<br/>Chapter 44: Dysphagia<br/>Chapter 45: Nausea, Vomiting, and Indigestion<br/>Chapter 46: Diarrhea and Constipation<br/>Chapter 47: Unintentional Weight Loss<br/>Chapter 48: Gastrointestinal Bleeding<br/>Chapter 49: Jaundice<br/>Chapter 50: Abdominal Swelling and Ascites<br/>Section 7: Alterations in Renal and Urinary Tract Function<br/>Chapter 51: Interstitial Cystitis/Bladder Pain Syndrome<br/>Chapter 52: Azotemia and Urinary Abnormalities<br/>Chapter 53: Fluid and Electrolyte Disturbances<br/>Chapter 54: Hypercalcemia and Hypocalcemia<br/>Chapter 55: Acidosis and Alkalosis<br/>Section 8: Alterations in the Skin<br/>Chapter 56: Approach to the Patient with a Skin Disorder<br/>Chapter 57: Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders<br/>Chapter 58: Skin Manifestations of Internal Disease<br/>Chapter 59: Immunologically Mediated Skin Diseases<br/>Chapter 60: Cutaneous Drug Reactions<br/>Chapter 61: Photosensitivity and Other Reactions to Sunlight<br/>Section 9: Hematologic Alterations<br/>Chapter 62: Interpreting Peripheral Blood Smears<br/>Chapter 63: Anemia and Polycythemia<br/>Chapter 64: Disorders of Granulocytes and Monocytes<br/>Chapter 65: Bleeding and Thrombosis<br/>Chapter 66: Enlargement of Lymph Nodes and Spleen<br/>Part 3: Pharmacology<br/>Chapter 67: Principles of Clinical Pharmacology<br/>Chapter 68: Pharmacogenomics<br/>Part 4: Oncology and Hematology<br/>Section 1: Neoplastic Disorders<br/>Chapter 69: Approach to the Patient with Cancer<br/>Chapter 70: Prevention and Early Detection of Cancer<br/>Chapter 71: Cancer Genetics<br/>Chapter 72: Cancer Cell Biology<br/>Chapter 73: Principles of Cancer Treatment<br/>Chapter 74: Infections in Patients with Cancer<br/>Chapter 75: Oncologic Emergencies<br/>Updated! Chapter 76: Cancer of the Skin<br/>Chapter 77: Head and Neck Cancer<br/>Chapter 78: Neoplasms of the Lung<br/>Chapter 79: Breast Cancer<br/>Chapter 80: Upper Gastrointestinal Tract Cancers<br/>Chapter 81: Lower Gastrointestinal Cancers<br/>Chapter 82: Tumors of the Liver and Biliary Tree<br/>Chapter 83: Pancreatic Cancer<br/>Chapter 84: Gastrointestinal Neuroendocrine Tumors<br/>Chapter 85: Renal Cell Carcinoma<br/>Chapter 86: Cancer of the Bladder and Urinary Tract<br/>Chapter 87: Benign and Malignant Diseases of the Prostate<br/>Chapter 88: Testicular Cancer<br/>Chapter 89: Gynecologic Malignancies<br/>Chapter 90: Primary and Metastatic Tumors of the Nervous System<br/>Chapter 91: Soft Tissue and Bone Sarcomas and Bone Metastases<br/>Chapter 92: Carcinoma of Unknown Primary<br/>Chapter 93: Paraneoplastic Syndromes: Endocrinologic/Hematologic<br/>Chapter 94: Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis<br/>Chapter 95: Cancer Survivorship and the Long-Term Impact of Cancer and Its Treatment<br/>Section 2: Hematopoietic Disorders<br/>Chapter 96: Hematopoietic Stem Cells<br/>Chapter 97: Iron Deficiency and Other Hypoproliferative Anemias<br/>Chapter 98: Disorders of Hemoglobin<br/>Chapter 99: Megaloblastic Anemias<br/>Chapter 100: Hemolytic Anemias<br/>Chapter 101: Anemia Due to Acute Blood Loss<br/>Chapter 102: Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia<br/>Chapter 103: Polycythemia Vera and Other Myeloproliferative Neoplasms<br/>Chapter 104: Acute Myeloid Leukemia<br/>Chapter 105: Chronic Myeloid Leukemia<br/>Chapter 106: Acute Lymphoid Leukemia<br/>Chapter 107: Chronic Lymphocytic Leukemia<br/>Chapter 108: Non-Hodgkin’s Lymphoma<br/>Chapter 109: Hodgkin’s Lymphoma<br/>Chapter 110: Less Common Lymphoid and Myeloid Malignancies<br/>Chapter 111: Plasma Cell Disorders<br/>Chapter 112: Amyloidosis<br/>Chapter 113: Transfusion Therapy and Biology<br/>Chapter 114: Hematopoietic Cell Transplantation<br/>Section 3: Disorders of Hemostasis<br/>Chapter 115: Disorders of Platelets and Vessel Wall<br/>Chapter 116: Coagulation Disorders<br/>Chapter 117: Arterial and Venous Thrombosis<br/>Chapter 118: Antiplatelet, Anticoagulant, and Fibrinolytic Drugs<br/>Part 5: Infectious Diseases<br/>Section 1: Basic Considerations in Infectious Diseases<br/>Chapter 119: Approach to the Patient with an Infectious Disease<br/>Chapter 120: Molecular Mechanisms of Microbial Pathogenesis<br/>Chapter 121: Microbial Genomics and Infectious Disease<br/>Updated! Chapter 122: Approach to the Acutely Ill Infected Febrile Patient<br/>Chapter 124: Health Recommendations for International Travel<br/>Chapter 123: Immunization Principles and Vaccine Use<br/>Chapter 125: Climate Change and Infectious Disease<br/>Section 2: Clinical Syndromes: Community-Acquired Infections<br/>Chapter 126: Pneumonia<br/>Chapter 127: Lung Abscess<br/>Chapter 128: Infective Endocarditis<br/>Chapter 129: Infections of the Skin, Muscles, and Soft Tissues<br/>Chapter 130: Infectious Arthritis<br/>Chapter 131: Osteomyelitis<br/>Chapter 132: Intraabdominal Infections and Abscesses<br/>Chapter 133: Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning<br/>Chapter 134: Clostridioides difficile Infection, Including Pseudomembranous Colitis<br/>Chapter 135: Urinary Tract Infections, Pyelonephritis, and Prostatitis<br/>Chapter 136: Sexually Transmitted Infections: Overview and Clinical Approach<br/>Updated! Chapter 137: Encephalitis<br/>Chapter 138: Acute Meningitis<br/>Chapter 139: Chronic and Recurrent Meningitis<br/>Chapter 140: Brain Abscess and Empyema<br/>Chapter 141: Infectious Complications of Bites<br/>Section 3: Clinical Syndromes: Health Care-Associated Infections<br/>Chapter 142: Infections Acquired in Health Care Facilities<br/>Chapter 143: Infections in Transplant Recipients<br/>Section 4: Therapy for Bacterial Diseases<br/>Chapter 144: Treatment and Prophylaxis of Bacterial Infections<br/>Chapter 145: Bacterial Resistance to Antimicrobial Agents<br/>Section 5: Diseases Caused by Gram-Positive Bacteria<br/>Chapter 146: Pneumococcal Infections<br/>Chapter 147: Staphylococcal Infections<br/>Chapter 148: Streptococcal Infections<br/>Chapter 149: Enterococcal Infections<br/>Chapter 150: Diphtheria and Other Corynebacterial Infections<br/>Chapter 151: Listeria monocytogenes Infections<br/>Chapter 152: Tetanus<br/>Chapter 153: Botulism<br/>Chapter 154: Gas Gangrene and Other Clostridial Infections<br/>Section 6: Diseases Caused by Gram-Negative Bacteria<br/>Chapter 155: Meningococcal Infections<br/>Chapter 156: Gonococcal Infections<br/>Chapter 157: Haemophilus and Moraxella Infections<br/>Chapter 158: Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria<br/>Chapter 159: Legionella Infections<br/>Chapter 160: Pertussis and Other Bordetella Infections<br/>Chapter 161: Diseases Caused by Gram-Negative Enteric Bacilli<br/>Chapter 162: Acinetobacter Infections<br/>Chapter 163: Helicobacter pylori Infections<br/>Chapter 164: Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species<br/>Chapter 165: Salmonellosis<br/>Updated! Chapter 166: Shigellosis<br/>Chapter 167: Infections Due to Campylobacter and Related Organisms<br/>Chapter 168: Cholera and Other Vibrioses<br/>Chapter 169: Brucellosis<br/>Chapter 170: Tularemia<br/>Chapter 171: Plague and Other Yersinia Infections<br/>Chapter 172: Bartonella Infections, Including Cat-Scratch Disease<br/>Chapter 173: Donovanosis<br/>Section 7: Miscellaneous Bacterial Infections<br/>Chapter 174: Nocardiosis<br/>Chapter 175: Actinomycosis<br/>Chapter 176: Whipple’s Disease<br/>Chapter 177: Infections Due to Mixed Anaerobic Organisms<br/>Section 8: Mycobacterial Diseases<br/>Chapter 178: Tuberculosis<br/>Chapter 179: Leprosy<br/>Chapter 180: Nontuberculous Mycobacterial Infections<br/>Chapter 181: Antimycobacterial Agents<br/>Section 9: Spirochetal Diseases<br/>Chapter 182: Syphilis<br/>Chapter 183: Endemic Treponematoses<br/>Updated! Chapter 184: Leptospirosis<br/>Chapter 185: Relapsing Fever and Borrelia miyamotoi Disease<br/>Chapter 186: Lyme Borreliosis<br/>Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae<br/>Chapter 187: Rickettsial Diseases<br/>Chapter 188: Infections Due to Mycoplasmas<br/>Chapter 189: Chlamydial Infections<br/>Section 11: Viral Diseases: General Considerations<br/>Chapter 190: Principles of Medical Virology<br/>Chapter 191: Antiviral Chemotherapy, Excluding Antiretroviral Drugs<br/>Section 12: Infections Due to DNA Viruses<br/>Chapter 192: Herpes Simplex Virus Infections<br/>Chapter 193: Varicella-Zoster Virus Infections<br/>Chapter 194: Epstein-Barr Virus Infections, Including Infectious Mononucleosis<br/>Chapter 195: Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8<br/>Chapter 196: Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections<br/>Chapter 197: Parvovirus Infections<br/>Chapter 198: Human Papillomavirus Infections<br/>Section 13: Infections Due to DNA and RNA Respiratory Viruses<br/>Chapter 199: Common Viral Respiratory Infections, Including COVID-19<br/>Chapter 200: Influenza<br/>Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses<br/>Chapter 201: The Human Retroviruses<br/>Chapter 202: Human Immunodeficiency Virus Disease: AIDS and Related Disorders<br/>Section 15: Infections Due to RNA Viruses<br/>Chapter 203: Viral Gastroenteritis<br/>Chapter 204: Enterovirus, Parechovirus, and Reovirus Infections<br/>Chapter 205: Measles (Rubeola)<br/>Chapter 206: Rubella (German Measles)<br/>Chapter 207: Mumps<br/>Chapter 208: Rabies and Other Rhabdovirus Infections<br/>Chapter 209: Arthropod-Borne and Rodent-Borne Virus Infections<br/>Chapter 210: Ebolavirus and Marburgvirus Infections<br/>Section 16: Fungal Infections<br/>Chapter 211: Pathogenesis, Diagnosis, and Treatment of Fungal Infections<br/>Chapter 212: Histoplasmosis<br/>Chapter 213: Coccidioidomycosis<br/>Chapter 214: Blastomycosis<br/>Chapter 215: Cryptococcosis<br/>Chapter 216: Candidiasis<br/>Chapter 217: Aspergillosis<br/>Chapter 218: Mucormycosis<br/>Chapter 219: Less Common Systemic Mycoses and Superficial Mycoses<br/>Chapter 220: Pneumocystis Infections<br/>Section 17: Protozoal and Helminthic Infections: General Considerations<br/>Chapter 221: Introduction to Parasitic Infections<br/>Chapter 222: Agents Used to Treat Parasitic Infections<br/>Section 18: Protozoal Infections<br/>Chapter 223: Amebiasis and Infection with Free-Living Amebae<br/>Chapter 224: Malaria<br/>Chapter 225: Babesiosis<br/>Chapter 226: Leishmaniasis<br/>Chapter 227: Chagas Disease and African Trypanosomiasis<br/>Chapter 228: Toxoplasma Infections<br/>Chapter 229: Protozoal Intestinal Infections and Trichomoniasis<br/>Section 19: Helminthic Infections<br/>Chapter 230: Introduction to Helminthic Infections<br/>Chapter 231: Trichinellosis and Other Tissue Nematode Infections<br/>Chapter 232: Intestinal Nematode Infections<br/>Chapter 233: Filarial and Related Infections<br/>Chapter 234: Schistosomiasis and Other Trematode Infections<br/>Chapter 235: Cestode Infections<br/>Part 6: Disorders of the Cardiovascular System<br/>Section 1: Introduction to Cardiovascular Disorders<br/>Chapter 236: Approach to the Patient with Possible Cardiovascular Disease<br/>Chapter 237: Basic Biology of the Cardiovascular System<br/>Chapter 238: Epidemiology of Cardiovascular Disease<br/>Section 2: Diagnosis of Cardiovascular Disorders<br/>Chapter 239: Physical Examination of the Cardiovascular System<br/>Chapter 240: Electrocardiography<br/>Chapter 241: Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging<br/>Chapter 242: Diagnostic Cardiac Catheterization and Coronary Angiography<br/>Section 3: Disorders of Rhythm<br/>Chapter 243: Principles of Clinical Cardiac Electrophysiology<br/>Chapter 244: The Bradyarrhythmias: Disorders of the Sinoatrial Node<br/>Chapter 245: The Bradyarrhythmias: Disorders of the Atrioventricular Node<br/>Chapter 246: Approach to Supraventricular Tachyarrhythmias<br/>Chapter 247: Physiologic and Nonphysiologic Sinus Tachycardia<br/>Chapter 248: Focal Atrial Tachycardia<br/>Chapter 249: Paroxysmal Supraventricular Tachycardias<br/>Chapter 250: Common Atrial Flutter and Macroreentrant and Multifocal Atrial Tachycardias<br/>Chapter 251: Atrial Fibrillation<br/>Chapter 252: Approach to Ventricular Arrhythmias<br/>Chapter 253: Premature Ventricular Contractions, Nonsustained Ventricular Tachycardia, and Accelerated Idioventricular Rhythm<br/>Chapter 254: Sustained Ventricular Tachycardia<br/>Chapter 255: Polymorphic Ventricular Tachycardia and Ventricular Fibrillation<br/>Chapter 256: Electrical Storm and Incessant Ventricular Tachycardia<br/>Section 4: Disorders of the Heart, Muscles, Valves, and Pericardium<br/>Chapter 257: Heart Failure: Pathophysiology and Diagnosis<br/>Chapter 258: Heart Failure: Management<br/>Chapter 259: Cardiomyopathy and Myocarditis<br/>Chapter 260: Cardiac Transplantation and Prolonged Assisted Circulation<br/>Chapter 261: Aortic Stenosis<br/>Chapter 262: Aortic Regurgitation<br/>Chapter 263: Mitral Stenosis<br/>Chapter 264: Mitral Regurgitation<br/>Chapter 265: Mitral Valve Prolapse<br/>Chapter 266: Tricuspid Valve Disease<br/>Chapter 267: Pulmonic Valve Disease<br/>Chapter 268: Multiple and Mixed Valvular Heart Disease<br/>Chapter 269: Congenital Heart Disease in the Adult<br/>Chapter 270: Pericardial Disease<br/>Chapter 271: Atrial Myxoma and Other Cardiac Tumors<br/>Chapter 272: Cardiac Trauma<br/>Section 5: Coronary and Peripheral Vascular Disease<br/>Chapter 273: Ischemic Heart Disease<br/>Chapter 274: Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)<br/>Chapter 275: ST-Segment Elevation Myocardial Infarction<br/>Chapter 276: Percutaneous Coronary Interventions and Other Interventional Procedures<br/>Chapter 277: Hypertension<br/>Chapter 278: Renovascular Disease<br/>Chapter 279: Deep-Venous Thrombosis and Pulmonary Thromboembolism<br/>Chapter 280: Diseases of the Aorta<br/>Chapter 281: Arterial Diseases of the Extremities<br/>Chapter 282: Chronic Venous Disease and Lymphedema<br/>Chapter 283: Pulmonary Hypertension<br/>Part 7: Disorders of the Respiratory System<br/>Section 1: Diagnosis of Respiratory Disorders<br/>Chapter 284: Approach to the Patient with Disease of the Respiratory System<br/>Chapter 285: Disturbances of Respiratory Function<br/>Chapter 286: Diagnostic Procedures in Respiratory Disease<br/>Section 2: Diseases of the Respiratory System<br/>Chapter 287: Asthma<br/>Chapter 288: Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia<br/>Chapter 289: Occupational and Environmental Lung Disease<br/>Chapter 291: Cystic Fibrosis<br/>Chapter 290: Bronchiectasis<br/>Chapter 292: Chronic Obstructive Pulmonary Disease<br/>Chapter 293: Interstitial Lung Disease<br/>Chapter 294: Disorders of the Pleura<br/>Chapter 295: Disorders of the Mediastinum<br/>Chapter 296: Disorders of Ventilation<br/>Chapter 297: Sleep Apnea<br/>Chapter 298: Lung Transplantation<br/>Chapter 299: Interventional Pulmonary Medicine<br/>Part 8: Critical Care Medicine<br/>Section 1: Respiratory Critical Care<br/>Chapter 300: Approach to the Patient with Critical Illness<br/>Chapter 301: Acute Respiratory Distress Syndrome<br/>Chapter 302: Mechanical Ventilatory Support<br/>Section 2: Shock and Cardiac Arrest<br/>Chapter 303: Approach to the Patient with Shock<br/>Chapter 304: Sepsis and Septic Shock<br/>Chapter 305: Cardiogenic Shock and Pulmonary Edema<br/>Chapter 306: Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death<br/>Section 3: Neurologic Critical Care<br/>Chapter 307: Nervous System Disorders in Critical Care<br/>Part 9: Disorders of the Kidney and Urinary Tract<br/>Chapter 308: Approach to the Patient with Renal Disease or Urinary Tract Disease<br/>Chapter 309: Cell Biology and Physiology of the Kidney<br/>Chapter 310: Acute Kidney Injury<br/>Chapter 311: Chronic Kidney Disease<br/>Chapter 312: Dialysis in the Treatment of Kidney Failure<br/>Chapter 313: Transplantation in the Treatment of Renal Failure<br/>Chapter 314: Glomerular Diseases<br/>Chapter 315: Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development<br/>Chapter 316: Tubulointerstitial Diseases of the Kidney<br/>Chapter 317: Vascular Injury to the Kidney<br/>Chapter 318: Nephrolithiasis<br/>Chapter 319: Urinary Tract Obstruction<br/>Chapter 320: Interventional Nephrology<br/>Part 10: Disorders of the Gastrointestinal System<br/>Section 1: Disorders of the Alimentary Tract<br/>Chapter 321: Approach to the Patient with Gastrointestinal Disease<br/>Chapter 322: Gastrointestinal Endoscopy<br/>Chapter 323: Diseases of the Esophagus<br/>Chapter 324: Peptic Ulcer Disease and Related Disorders<br/>Chapter 325: Disorders of Absorption<br/>Chapter 326: Inflammatory Bowel Disease<br/>Chapter 327: Irritable Bowel Syndrome<br/>Chapter 328: Diverticular Disease and Common Anorectal Disorders<br/>Chapter 329: Mesenteric Vascular Insufficiency<br/>Chapter 330: Acute Intestinal Obstruction<br/>Chapter 331: Acute Appendicitis and Peritonitis<br/>Section 2: Nutrition<br/>Chapter 332: Nutrient Requirements and Dietary Assessment<br/>Chapter 333: Vitamin and Trace Mineral Deficiency and Excess<br/>Chapter 334: Malnutrition and Nutritional Assessment<br/>Chapter 335: Enteral and Parenteral Nutrition<br/>Section 3: Liver and Biliary Tract Disease<br/>Chapter 336: Approach to the Patient with Liver Disease<br/>Chapter 337: Evaluation of Liver Function<br/>Chapter 338: The Hyperbilirubinemias<br/>Chapter 339: Acute Viral Hepatitis<br/>Chapter 340: Toxic and Drug-Induced Hepatitis<br/>Chapter 341: Chronic Hepatitis<br/>Chapter 342: Alcohol-Associated Liver Disease<br/>Chapter 343: Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis<br/>Chapter 344: Cirrhosis and Its Complications<br/>Chapter 345: Liver Transplantation<br/>Chapter 346: Diseases of the Gallbladder and Bile Ducts<br/>Section 4: Disorders of the Pancreas<br/>Chapter 347: Approach to the Patient with Pancreatic Disease<br/>Chapter 348: Acute and Chronic Pancreatitis<br/>Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders<br/>Section 1: The Immune System in Health and Disease<br/>Chapter 349: Introduction to the Immune System<br/>Chapter 350: Mechanisms of Regulation and Dysregulation of the Immune System<br/>Chapter 351: Primary Immune Deficiency Diseases<br/>Section 2: Disorders of Immune-Mediated Injury<br/>Chapter 352: Urticaria, Angioedema, and Allergic Rhinitis<br/>Chapter 353: Anaphylaxis<br/>Chapter 354: Mastocytosis<br/>Chapter 355: Autoimmunity and Autoimmune Diseases<br/>Chapter 356: Systemic Lupus Erythematosus<br/>Chapter 357: Antiphospholipid Syndrome<br/>Chapter 358: Rheumatoid Arthritis<br/>Chapter 359: Acute Rheumatic Fever<br/>Chapter 360: Systemic Sclerosis (Scleroderma) and Related Disorders<br/>Chapter 361: Sjögren’s Syndrome<br/>Chapter 362: Spondyloarthritis<br/>Chapter 363: The Vasculitis Syndromes<br/>Chapter 364: Behçet Syndrome<br/>Chapter 365: Inflammatory Myopathies<br/>Chapter 366: Relapsing Polychondritis<br/>Chapter 367: Sarcoidosis<br/>Chapter 368: IgG4-Related Disease<br/>Chapter 369: Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases<br/>Section 3: Disorders of the Joints and Adjacent Tissues<br/>Chapter 370: Approach to Articular and Musculoskeletal Disorders<br/>Chapter 371: Osteoarthritis<br/>Chapter 372: Gout and Other Crystal-Associated Arthropathies<br/>Chapter 373: Fibromyalgia<br/>Chapter 374: Arthritis Associated with Systemic Disease, and Other Arthritides<br/>Chapter 375: Periarticular Disorders of the Extremities<br/>Part 12: Endocrinology and Metabolism<br/>Section 1: Endocrinology<br/>Chapter 376: Approach to the Patient with Endocrine Disorders<br/>Chapter 377: Mechanisms of Hormone Action<br/>Chapter 378: Physiology of Anterior Pituitary Hormones<br/>Chapter 379: Hypopituitarism<br/>Chapter 380: Pituitary Tumor Syndromes<br/>Chapter 381: Disorders of the Neurohypophysis<br/>Chapter 382: Thyroid Gland Physiology and Testing<br/>Chapter 383: Hypothyroidism<br/>Chapter 384: Hyperthyroidism and Other Causes of Thyrotoxicosis<br/>Chapter 385: Thyroid Nodular Disease and Thyroid Cancer<br/>Chapter 386: Disorders of the Adrenal Cortex<br/>Chapter 387: Pheochromocytoma<br/>Chapter 388: Multiple Endocrine Neoplasia Syndromes<br/>Chapter 389: Autoimmune Polyendocrine Syndromes<br/>Section 2: Sex- and Gender-Based Medicine<br/>Chapter 390: Sex Development<br/>Chapter 391: Disorders of the Testes and Male Reproductive System<br/>Chapter 392: Disorders of the Female Reproductive System<br/>Chapter 393: Menstrual Disorders and Pelvic Pain<br/>Chapter 394: Hirsutism<br/>Chapter 395: Menopause and Postmenopausal Hormone Therapy<br/>Chapter 396: Infertility and Contraception<br/>Chapter 397: Sexual Dysfunction<br/>Chapter 398: Women’s Health<br/>Chapter 399: Men’s Health<br/>Chapter 400: Lesbian, Gay, Bisexual, and Transgender (LGBT) Health<br/>Section 3: Obesity, Diabetes Mellitus, and Metabolic Syndrome<br/>Chapter 401: Pathobiology of Obesity<br/>Chapter 402: Evaluation and Management of Obesity<br/>Chapter 404: Diabetes Mellitus: Management and Therapies<br/>Chapter 403: Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology<br/>Chapter 405: Diabetes Mellitus: Complications<br/>Chapter 406: Hypoglycemia<br/>Chapter 407: Disorders of Lipoprotein Metabolism<br/>Chapter 408: The Metabolic Syndrome<br/>Section 4: Disorders of Bone and Mineral Metabolism<br/>Chapter 409: Bone and Mineral Metabolism in Health and Disease<br/>Chapter 410: Disorders of the Parathyroid Gland and Calcium Homeostasis<br/>Chapter 411: Osteoporosis<br/>Chapter 412: Paget’s Disease and Other Dysplasias of Bone<br/>Section 5: Disorders of Intermediary Metabolism<br/>Chapter 413: Heritable Disorders of Connective Tissue<br/>Chapter 414: Hemochromatosis<br/>Chapter 415: Wilson’s Disease<br/>Chapter 416: The Porphyrias<br/>Chapter 417: Disorders of Purine and Pyrimidine Metabolism<br/>Chapter 418: Lysosomal Storage Diseases<br/>Chapter 419: Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism<br/>Chapter 420: Inherited Disorders of Amino Acid Metabolism in Adults<br/>Chapter 421: Inherited Defects of Membrane Transport<br/>Part 13: Neurologic Disorders<br/>Section 1: Diagnosis of Neurologic Disorders<br/>Chapter 422: Approach to the Patient with Neurologic Disease<br/>Chapter 423: Neuroimaging in Neurologic Disorders<br/>Chapter 424: Pathobiology of Neurologic Diseases<br/>Section 2: Diseases of the Central Nervous System<br/>Chapter 425: Seizures and Epilepsy<br/>Chapter 426: Introduction to Cerebrovascular Diseases<br/>Updated! Chapter 427: Ischemic Stroke<br/>Chapter 428: Intracranial Hemorrhage<br/>Chapter 429: Subarachnoid Hemorrhage<br/>Chapter 430: Migraine and Other Primary Headache Disorders<br/>Chapter 431: Alzheimer’s Disease<br/>Chapter 432: Frontotemporal Dementia<br/>Chapter 433: Vascular Dementia<br/>Chapter 434: Dementia with Lewy Bodies<br/>Updated! Chapter 435: Parkinson’s Disease<br/>Chapter 436: Tremor, Chorea, and Other Movement Disorders<br/>Chapter 437: Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases<br/>Chapter 438: Prion Diseases<br/>Chapter 439: Ataxic Disorders<br/>Chapter 440: Disorders of the Autonomic Nervous System<br/>Chapter 441: Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders<br/>Chapter 442: Diseases of the Spinal Cord<br/>Chapter 443: Concussion and Other Traumatic Brain Injuries<br/>Chapter 444: Multiple Sclerosis<br/>Chapter 445: Neuromyelitis Optica<br/>Section 3: Nerve and Muscle Disorders<br/>Chapter 446: Peripheral Neuropathy<br/>Chapter 447: Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies<br/>Chapter 448: Myasthenia Gravis and Other Diseases of the Neuromuscular Junction<br/>Updated! Chapter 449: Muscular Dystrophies and Other Muscle Diseases<br/>Section 4: Chronic Fatigue Syndrome<br/>Chapter 450: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<br/>Section 5: Psychiatric and Addiction Disorders<br/>Chapter 451: Biology of Psychiatric Disorders<br/>Chapter 452: Psychiatric Disorders<br/>Chapter 453: Alcohol and Alcohol Use Disorders<br/>Chapter 454: Nicotine Addiction<br/>Chapter 455: Marijuana and Marijuana Use Disorders<br/>Chapter 456: Opioid-Related Disorders<br/>Chapter 457: Cocaine, Other Psychostimulants, and Hallucinogens<br/>Part 14: Poisoning, Drug Overdose, and Envenomation<br/>Chapter 458: Heavy Metal Poisoning<br/>Chapter 459: Poisoning and Drug Overdose<br/>Chapter 460: Disorders Caused by Venomous Snakebites and Marine Animal Exposures<br/>Chapter 461: Ectoparasite Infestations and Arthropod Injuries<br/>Part 15: Disorders Associated with Environmental Exposures<br/>Chapter 462: Altitude Illness<br/>Chapter 463: Hyperbaric and Diving Medicine<br/>Chapter 464: Hypothermia and Peripheral Cold Injuries<br/>Chapter 465: Heat-Related Illnesses<br/>Part 16: Genes, the Environment, and Disease<br/>Chapter 466: Principles of Human Genetics<br/>Chapter 467: The Practice of Genetics in Clinical Medicine<br/>Chapter 468: Mitochondrial DNA and Heritable Traits and Diseases<br/>Chapter 469: Telomere Disease<br/>Chapter 470: Gene- and Cell-Based Therapy in Clinical Medicine<br/>Chapter 471: The Human Microbiome<br/>Part 17: Global Medicine<br/>Chapter 472: Global Issues in Medicine<br/>Chapter 473: Emerging and Reemerging Infectious Diseases<br/>Chapter 474: Primary Care and Global Health<br/>Chapter 475: Health Effects of Climate Change<br/>Part 18: Aging<br/>Chapter 476: Biology of Aging<br/>Chapter 477: Caring for the Geriatric Patient<br/>Part 19: Consultative Medicine<br/>Chapter 478: Approach to Medical Consultation<br/>Chapter 479: Medical Disorders During Pregnancy<br/>Chapter 480: Medical Evaluation of the Surgical Patient<br/>Part 20: Frontiers<br/>Chapter 481: Behavioral Economics and Health<br/>Chapter 482: Complementary and Integrative Therapies and Practices<br/>Chapter 483: The Role of Epigenetics in Disease and Treatment<br/>Chapter 484: Applications of Stem Cell Biology in Clinical Medicine<br/>Chapter 485: The Role of Circadian Biology in Health and Disease<br/>Chapter 486: Network Medicine: Systems Biology in Health and Disease<br/>Chapter 487: Emerging Neurotherapeutic Technologies<br/>Chapter 488: Machine Learning and Augmented Intelligence in Clinical Medicine<br/>Chapter 489: Metabolomics<br/>Chapter 490: Circulating Nucleic Acids as Liquid Biopsies and Noninvasive Disease Biomarkers<br/>Chapter 491: Protein Folding Disorders<br/>Chapter 492: Novel Approaches to Diseases of Unknown Etiology<br/>Part 21: Video Collection<br/>Chapter V1: Video Library of Gait Disorders<br/>Chapter V2: Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders<br/>Chapter V3: Video Library of Neuro-Ophthalmology<br/>Chapter V4: Examination of the Comatose Patient<br/>Chapter V5: Video Atlas of Gastrointestinal Endoscopic Lesions<br/>Chapter V6: The Neurologic Screening Exam<br/>Chapter V7: Video Atlas of the Detailed Neurologic Examination<br/>Part 22: Supplementary Topics<br/>Chapter S1: Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples<br/>Chapter S2: Cerebrospinal Fluid Disturbances: Case Examples<br/>Chapter S3: Microbial Bioterrorism<br/>Chapter S4: Chemical Terrorism<br/>Chapter S5: Radiation Terrorism<br/>Chapter S6: Infections in War Veterans<br/>Chapter S7: Health Care for Military Veterans<br/>Chapter S8: Primary Immunodeficiencies Associated with (or Secondary to) Other Diseases<br/>Chapter S9: Technique of Lumbar Puncture<br/>Chapter S10: The Clinical Laboratory in Modern Health Care<br/>Chapter S11: Laboratory Diagnosis of Infectious Diseases<br/>Chapter S12: Laboratory Diagnosis of Parasitic Infections<br/>Part 23: Atlases<br/>Chapter A1: Atlas of Rashes Associated with Fever<br/>Chapter A2: Atlas of Blood Smears of Malaria and Babesiosis<br/>Chapter A3: Atlas of Oral Manifestations of Disease<br/>Chapter A4: Atlas of Urinary Sediments and Renal Biopsies<br/>Chapter A5: Atlas of Skin Manifestations of Internal Disease<br/>Chapter A6: Atlas of Hematology<br/>Chapter A7: Atlas of Electrocardiography<br/>Chapter A8: Atlas of Cardiac Arrhythmias<br/>Chapter A9: Atlas of Noninvasive Imaging<br/>Chapter A10: Atlas of Atherosclerosis<br/>Chapter A11: Atlas of Percutaneous Revascularization and Adult Structural Heart Interventions<br/>Chapter A12: Atlas of Chest Imaging<br/>Chapter A13: Atlas of Liver Biopsies<br/>Chapter A14: Atlas of the Vasculitic Syndromes<br/>Chapter A15: Atlas of Clinical Manifestations of Endocrine and Metabolic Diseases<br/>Chapter A16: Atlas of Neuroimaging<br/>Part 24: Clinical Procedure Tutorials<br/>Chapter CP1: Clinical Procedure Tutorial: Central Venous Catheter Placement<br/>Chapter CP2: Clinical Procedure Tutorial: Thoracentesis<br/>Chapter CP3: Clinical Procedure Tutorial: Abdominal Paracentesis<br/>Chapter CP4: Clinical Procedure Tutorial: Endotracheal Intubation<br/>Chapter CP5: Clinical Procedure Tutorial: Percutaneous Arterial Blood Gas Sampling<br/>Chapter CP6: Clinical Procedure Tutorial: Lumbar Puncture<br/>Chapter CP7: Clinical Procedures Tutorial: Phlebotomy<br/>Chapter CP8: Clinical Procedures Tutorial: Insertion of Female Urethral Catheter<br/>Chapter CP9: Clinical Procedures Tutorial: Insertion of Male Urethral Catheter<br/>Chapter CP10: Clinical Procedures Tutorial: Fine Needle Aspiration of Breast Cyst<br/>Chapter CP11: Clinical Procedures Tutorial: IV Insertion<br/>Chapter CP12: Clinical Procedures Tutorial: Fine Needle Aspiration of Thyroid Nodules<br/>Chapter CP13: Clinical Procedures Tutorial: Gynecologic Examination with Pap Smear<br/>Chapter CP14: Clinical Procedures Tutorial: Knee Arthrocentesis<br/>Chapter CP15: Clinical Procedures Tutorial: Pericardiocentesis<br/>Chapter CP16: Clinical Procedures Tutorial: Bone Marrow Biopsy<br/>Chapter CP17: Clinical Procedures Tutorial: Basic Suturing |